(3,4-Dimethoxy-phenyl)-[2-(diphenyl-phosphinoyl)-pyrrolidin-1-yl]-methanone

Base Information

• Chemical Name: (3,4-Dimethoxy-phenyl)-[2-(diphenyl-phosphinoyl)-pyrrolidin-1-yl]-methanone
• CAS No.: 184356-13-6
• Molecular Formula: C₂₅H₂₆NO₄P
• Molecular Weight: 435.459
• Mol file: 184356-13-6.mol

Synonyms:(3,4-Dimethoxy-phenyl)-[2-(diphenyl-phosphinoyl)-pyrrolidin-1-yl]-methanone

Chemical Property of (3,4-Dimethoxy-phenyl)-[2-(diphenyl-phosphinoyl)-pyrrolidin-1-yl]-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3,4-Dimethoxy-phenyl)-[2-(diphenyl-phosphinoyl)-pyrrolidin-1-yl]-methanone

There total 2 articles about (3,4-Dimethoxy-phenyl)-[2-(diphenyl-phosphinoyl)-pyrrolidin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(diphenylphosphoryl)pyrrolidine (144630-67-1) + 3,4-dimethoxybenzoic acid chloride (3535-37-3) → (3,4-Dimethoxy-phenyl)-[2-(diphenyl-phosphinoyl)-pyrrolidin-1-yl]-methanone (184356-13-6)

Guidance literature:

With triethylamine; In toluene; Heating;

DOI:10.1016/0040-4039(96)01765-0

Reference yield:

Diphenylphosphine oxide (4559-70-0) → (3,4-Dimethoxy-phenyl)-[2-(diphenyl-phosphinoyl)-pyrrolidin-1-yl]-methanone (184356-13-6)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / Heating

2: 75 percent / Et₃N / toluene

With triethylamine; In toluene; 1: Addition / 2: Acylation;

DOI:10.1002/(SICI)1099-0690(199909)1999:9<2345::AID-EJOC2345>3.0.CO;2-P

Reference yield: 59.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (3,4-Dimethoxy-phenyl)-[2-(diphenyl-phosphinoyl)-pyrrolidin-1-yl]-methanone (184356-13-6) → (3,4-Dimethoxy-phenyl)-(2-methylene-pyrrolidin-1-yl)-methanone (184356-21-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; 1.) from -78 deg C to room temp.; 2.) from -30 deg C to room temp.;

DOI:10.1016/0040-4039(96)01765-0

upstream raw materials:

2-(diphenylphosphoryl)pyrrolidine

3,4-dimethoxybenzoic acid chloride

Diphenylphosphine oxide

Downstream raw materials:

(3,4-Dimethoxy-phenyl)-(2-methylene-pyrrolidin-1-yl)-methanone

{2-[1-Benzo[1,3]dioxol-5-yl-meth-(Z)-ylidene]-pyrrolidin-1-yl}-(3,4-dimethoxy-phenyl)-methanone

{2-[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-pyrrolidin-1-yl}-(3,4-dimethoxy-phenyl)-methanone

1-(3,4-dimethoxyphenyl)-2-(pyrrolidin-2-yl)ethan-1-one