1,3-dipropyl-8-{4-[3-(4-trifluoromethylphenyl)prop-2-ynyloxy]phenyl}3,7-dihydropurine-2,6-dione

Base Information

Chemical Name:1,3-dipropyl-8-{4-[3-(4-trifluoromethylphenyl)prop-2-ynyloxy]phenyl}3,7-dihydropurine-2,6-dione
CAS No.:1188541-46-9
Molecular Formula:C₂₇H₂₅F₃N₄O₃
Molecular Weight:510.516
Hs Code.:

Synonyms:1,3-dipropyl-8-{4-[3-(4-trifluoromethylphenyl)prop-2-ynyloxy]phenyl}3,7-dihydropurine-2,6-dione

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Chemical Property of 1,3-dipropyl-8-{4-[3-(4-trifluoromethylphenyl)prop-2-ynyloxy]phenyl}3,7-dihydropurine-2,6-dione

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Technology Process of 1,3-dipropyl-8-{4-[3-(4-trifluoromethylphenyl)prop-2-ynyloxy]phenyl}3,7-dihydropurine-2,6-dione

There total 9 articles about 1,3-dipropyl-8-{4-[3-(4-trifluoromethylphenyl)prop-2-ynyloxy]phenyl}3,7-dihydropurine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₃₉F₃N₄O₄Si

: 1188541-46-9
1,3-dipropyl-8-{4-[3-(4-trifluoromethylphenyl)prop-2-ynyloxy]phenyl}3,7-dihydropurine-2,6-dione

Guidance literature:: With hydrogenchloride; In ethanol; at 80 ℃; for 2h;
DOI:10.1016/j.ejmech.2017.04.014

Reference yield:

: 531506-41-9
8-[4-(phenylmethoxy)phenyl]-1,3-dipropyl-1,3,7-trihydropurine-2,6-dione

: 1188541-46-9
1,3-dipropyl-8-{4-[3-(4-trifluoromethylphenyl)prop-2-ynyloxy]phenyl}3,7-dihydropurine-2,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: hydrogen; palladium 10% on activated carbon / dichloromethane; methanol / 20 °C

3: potassium carbonate / acetone / 5 h / Reflux

4: hydrogenchloride / ethanol / 2 h / 80 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2017.04.014

Reference yield:

: 455-13-0
4-Iodobenzotrifluoride

: 1188541-46-9
1,3-dipropyl-8-{4-[3-(4-trifluoromethylphenyl)prop-2-ynyloxy]phenyl}3,7-dihydropurine-2,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / diethylamine / 20 h / Inert atmosphere

2: phosphorus tribromide / dichloromethane / 3 h / -50 - 0 °C

3: potassium carbonate / acetone / 5 h / Reflux

4: hydrogenchloride / ethanol / 2 h / 80 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; phosphorus tribromide; potassium carbonate; In ethanol; dichloromethane; diethylamine; acetone;
DOI:10.1016/j.ejmech.2017.04.014