1-(4-Bromo-phenyl)-3-azabicyclo[3.1.0]hexane

Base Information

• Chemical Name: 1-(4-Bromo-phenyl)-3-azabicyclo[3.1.0]hexane
• CAS No.: 86215-40-9
• Molecular Formula: C11H12 Br N
• Molecular Weight: 238.127
• Hs Code.: 2933990090
• Mol file: 86215-40-9.mol

Synonyms:3-Azabicyclo[3.1.0]hexane,1-(4-bromophenyl)-, (?à)-; (?à)-1-(4-Bromophenyl)-3-azabicyclo[3.1.0]hexane;1-(4-Bromophenyl)-3-azabicyclo[3.1.0]hexane

Chemical Property of 1-(4-Bromo-phenyl)-3-azabicyclo[3.1.0]hexane

Chemical Property:

• PSA: 12.03000
• LogP: 2.63880

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-(4-BROMO-PHENYL)-3-AZABICYCLO[3.1.0]HEXANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-Bromo-phenyl)-3-azabicyclo[3.1.0]hexane

There total 7 articles about 1-(4-Bromo-phenyl)-3-azabicyclo[3.1.0]hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1-(p-Bromphenyl)-1,2-cyclopropan-dicarboximid (66504-48-1) → 1-(4-bromophenyl)-3-azabicyclo[3.1.0]hexane (86215-40-9)

Guidance literature:

With borane; In tetrahydrofuran; at 100 ℃; for 1h;

DOI:10.1021/jm00137a002

Reference yield:

(4-bromo-phenyl)-acetic acid methyl ester (41841-16-1) → 1-(4-bromophenyl)-3-azabicyclo[3.1.0]hexane (86215-40-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 97 percent / NBS, 48percent aq. HBr / CCl₄ / Heating

2: 50 percent / NaOMe / diethyl ether / 24 h / Ambient temperature

3: 98 percent / KOH / ethanol; H₂O / 6 h / Heating

4: 40 percent / urea / xylene / Heating

5: 68 percent / BH₃ / tetrahydrofuran / 1 h / 100 °C

With potassium hydroxide; N-Bromosuccinimide; borane; hydrogen bromide; sodium methylate; urea; In tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; water; xylene;

DOI:10.1021/jm00137a002

Reference yield:

(1R,2S)-1-(4-Bromo-phenyl)-cyclopropane-1,2-dicarboxylic acid (77053-77-1) → 1-(4-bromophenyl)-3-azabicyclo[3.1.0]hexane (86215-40-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / urea / xylene / Heating

2: 68 percent / BH₃ / tetrahydrofuran / 1 h / 100 °C

With borane; urea; In tetrahydrofuran; xylene;

DOI:10.1021/jm00137a002

upstream raw materials:

1-(p-Bromphenyl)-1,2-cyclopropan-dicarboximid

(4-bromo-phenyl)-acetic acid methyl ester

(1R,2S)-1-(4-Bromo-phenyl)-cyclopropane-1,2-dicarboxylic acid

(1R,2S)-1-(4-Bromo-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester

Downstream raw materials:

1-(4-morpholin-4-yl-phenyl)-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester

1-(4-morpholin-4-yl-phenyl)-3-(2,2,2-trifluoro-ethyl)-3-aza-bicyclo[3.1.0]hexane

3-(2-methoxy-ethyl)-1-(4-morpholin-4-yl-phenyl)-3-aza-bicyclo[3.1.0]hexane

1-(4-pyrrolidin-1-yl-phenyl)-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester

Refernces

• 1、 Epstein, Joseph W.,Brabander, Herbert J.,Fanshawe, William J.,Hofmann, Corris M.,McKenzie, Thomas C.,et al.. "1-Aryl-3-azabicyclohexanes, a New Series of Nonnarcotic Analgesic Agents". . p. 481 - 490. Retrieved 2007/10/02.