Diethyl (2,3,4,6-tetra-O-benzyl-1-C-(2-thiazolyl)-α-D-galactopyranosyl)phosphonate

Base Information

Chemical Name:Diethyl (2,3,4,6-tetra-O-benzyl-1-C-(2-thiazolyl)-α-D-galactopyranosyl)phosphonate
CAS No.:213529-14-7
Molecular Formula:C₄₁H₄₆NO₈PS
Molecular Weight:743.858
Hs Code.:

Synonyms:Diethyl (2,3,4,6-tetra-O-benzyl-1-C-(2-thiazolyl)-α-D-galactopyranosyl)phosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Diethyl (2,3,4,6-tetra-O-benzyl-1-C-(2-thiazolyl)-α-D-galactopyranosyl)phosphonate

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Technology Process of Diethyl (2,3,4,6-tetra-O-benzyl-1-C-(2-thiazolyl)-α-D-galactopyranosyl)phosphonate

There total 3 articles about Diethyl (2,3,4,6-tetra-O-benzyl-1-C-(2-thiazolyl)-α-D-galactopyranosyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 350484-55-8
2,3,4,6-Tetra-O-benzyl-1-C-(2-thiazolyl)-α-D-galactopyranosyl diethyl phosphite

: 213529-14-7
Diethyl (2,3,4,6-tetra-O-benzyl-1-C-(2-thiazolyl)-α-D-galactopyranosyl)phosphonate

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; In dichloromethane; at 0 ℃; for 0.25h;
DOI:10.1002/1521-3765(20010401)7:7<1371::AID-CHEM1371>3.0.CO;2-J

Reference yield: 84.0%

: 160584-11-2
1-O-Acetyl-2,3,4,6-tetra-O-benzyl-1-(2-thiazolyl)-α-D-galactopyranose

: 122-52-1
triethyl phosphite

: 213529-14-7
Diethyl (2,3,4,6-tetra-O-benzyl-1-C-(2-thiazolyl)-α-D-galactopyranosyl)phosphonate

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; In dichloromethane; for 0.25h; Ambient temperature;
DOI:10.1016/S0040-4020(98)00539-0

Reference yield:

: 160701-76-8
2,3,4,6-Tetra-O-benzyl-1-(2-thiazolyl)-α-D-galactopyranose

: 213529-14-7
Diethyl (2,3,4,6-tetra-O-benzyl-1-C-(2-thiazolyl)-α-D-galactopyranosyl)phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: i-Pr₂EtN / CH₂Cl₂ / 0.33 h / 20 °C

2: 90 percent / TMSOTf; 4 Angstroem molecular sieves / CH₂Cl₂ / 0.25 h / 0 °C

With trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1002/1521-3765(20010401)7:7<1371::AID-CHEM1371>3.0.CO;2-J