Technology Process of 1,1',1''-(5-methylhex-4-en-1-yne-1,3,3-triyl)tribenzene
There total 10 articles about 1,1',1''-(5-methylhex-4-en-1-yne-1,3,3-triyl)tribenzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
isopropyltriphenylphosphonium iodide;
With
potassium hexamethylsilazane;
In
toluene;
at 0 ℃;
for 0.5h;
2,2,4-triphenylbut-3-ynal;
In
toluene;
at -78 - 0 ℃;
for 6h;
DOI:10.1021/ol202104c
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triphenylphosphine / dichloromethane / 0.17 h / 0 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 °C
3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 2 h / 70 °C
4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2 h / 0 - 20 °C / pH 7 / aq. phosphate buffer
5.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane
6.1: potassium hexamethylsilazane / toluene / 0.5 h / 0 °C
6.2: 6 h / -78 - 0 °C
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; potassium hexamethylsilazane; sodium hydrogencarbonate; Dess-Martin periodane; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
3.1: Sonogashira coupling / 6.1: Wittig reaction / 6.2: Wittig reaction;
DOI:10.1021/ol202104c
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 °C
2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 2 h / 70 °C
3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2 h / 0 - 20 °C / pH 7 / aq. phosphate buffer
4.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane
5.1: potassium hexamethylsilazane / toluene / 0.5 h / 0 °C
5.2: 6 h / -78 - 0 °C
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; potassium hexamethylsilazane; sodium hydrogencarbonate; Dess-Martin periodane; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
2.1: Sonogashira coupling / 5.1: Wittig reaction / 5.2: Wittig reaction;
DOI:10.1021/ol202104c
