4-methyl-N-cinnamylbenzamide

Base Information

• Chemical Name: 4-methyl-N-cinnamylbenzamide
• CAS No.: 129906-72-5
• Molecular Formula: C₁₇H₁₇NO
• Molecular Weight: 251.328
• Mol file: 129906-72-5.mol

Synonyms:4-methyl-N-cinnamylbenzamide

Chemical Property of 4-methyl-N-cinnamylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-methyl-N-cinnamylbenzamide

There total 2 articles about 4-methyl-N-cinnamylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + dimethyl sulfoxide (67-68-5,8070-53-9) + para-methylbenzamide (619-55-6) → 4-methyl-N-cinnamylbenzamide (129906-72-5)

Guidance literature:

With dipotassium peroxodisulfate; silver(I) acetate; cobalt acetylacetonate; at 130 ℃; for 12h; regioselective reaction;

DOI:10.1021/acs.orglett.9b02462

Reference yield:

(E)-cinnamylamine (4335-60-8,4360-51-4,4226-59-9) + 4-methyl-benzoyl chloride (874-60-2) → 4-methyl-N-cinnamylbenzamide (129906-72-5)

Guidance literature:

With triethylamine; In dichloromethane; Heating;

DOI:10.1055/s-2006-926365

Reference yield:

4-methyl-N-cinnamylbenzamide (129906-72-5) → 4-methyl-N-(3-phenyl-allyl)-benzimidoyl chloride

Guidance literature:

With (PhO)3P*Cl₂; triethylamine; In toluene; at -25 ℃; for 3h;

DOI:10.1055/s-2006-926365

upstream raw materials:

(E)-cinnamylamine

4-methyl-benzoyl chloride

styrene

dimethyl sulfoxide