2-Methyl-2-[6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-yl]propanoic acid

Base Information

Chemical Name:2-Methyl-2-[6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-yl]propanoic acid
CAS No.:1034045-77-6
Molecular Formula:C₂₄H₁₉F₆N₃O₅S
Molecular Weight:575.488
Hs Code.:

Synonyms:2-Methyl-2-[6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-yl]propanoic acid

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Chemical Property of 2-Methyl-2-[6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-yl]propanoic acid

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Technology Process of 2-Methyl-2-[6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-yl]propanoic acid

There total 3 articles about 2-Methyl-2-[6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-yl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1039716-05-6
C₂₄H₁₈F₆N₄O₃S

: 1034045-77-6
2-Methyl-2-[6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-yl]propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran

2: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; diisobutylaluminium hydride; In tetrahydrofuran; water; tert-butyl alcohol; 2: Pinnick oxidation;
DOI:10.1016/j.bmc.2012.03.029

Reference yield:

: 1034047-50-1
C₃₁H₂₄F₆N₄O₃S

: 1034045-77-6
2-Methyl-2-[6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-yl]propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: trimethylsilyl iodide / acetonitrile

2: diisobutylaluminium hydride / tetrahydrofuran

3: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; trimethylsilyl iodide; diisobutylaluminium hydride; In tetrahydrofuran; water; acetonitrile; tert-butyl alcohol; 3: Pinnick oxidation;
DOI:10.1016/j.bmc.2012.03.029

Reference yield:

: 1039716-07-8
C₂₄H₁₉F₆N₃O₄S

: 1034045-77-6
2-Methyl-2-[6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-yl]propanoic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol;
DOI:10.1016/j.bmc.2012.03.029