1H-Indole,7-acetonitrile

Base Information

• Chemical Name: 1H-Indole,7-acetonitrile
• CAS No.: 82199-98-2
• Molecular Formula: C₁₀H₈N₂
• Molecular Weight: 156.187
• Hs Code.: 2933990090
• Mol file: 82199-98-2.mol

Synonyms:(1H-Indol-7-yl)acetonitrile;Indole-7-acetonitrile

Chemical Property of 1H-Indole,7-acetonitrile

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.673
• Boiling Point: 374.108°C at 760 mmHg
• Flash Point: 127.557°C
• PSA: 39.58000
• Density: 1.219g/cm³
• LogP: 2.23398
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1H-Indole-7-acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole,7-acetonitrile

There total 5 articles about 1H-Indole,7-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

1H-indole-7-carbaldehyde (1074-88-0) + diethyl cyanophosphonate (2942-58-7) → 7-(cyanomethyl)indole (82199-98-2)

Guidance literature:

1H-indole-7-carbaldehyde; diethyl cyanophosphonate; With lithium cyanide; In tetrahydrofuran; at 20 ℃;

With samarium diiodide; tert-butyl alcohol; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/S0040-4039(03)00427-1

Reference yield:

indole (120-72-9) + lithioacetonitrile (99749-00-5) → 4-(cyanomethyl)indole (30933-66-5) + 7-(cyanomethyl)indole (82199-98-2)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(01)93270-3

Reference yield:

LiCN + 1H-indole-7-carbaldehyde (1074-88-0) + (EtO)2P(O)CN → 7-(cyanomethyl)indole (82199-98-2)

Guidance literature:

In tetrahydrofuran; tert-butyl alcohol;

upstream raw materials:

indole

lithioacetonitrile

1H-indole-7-carbaldehyde

diethyl cyanophosphonate