7-[(2,5-diphenyl-3,4-dihydro-2H-pyrazol-3-yl)methyl]quinolin-8-ol

Base Information

• Chemical Name: 7-[(2,5-diphenyl-3,4-dihydro-2H-pyrazol-3-yl)methyl]quinolin-8-ol
• CAS No.: 213411-02-0
• Molecular Formula: C₂₅H₂₁N₃O
• Molecular Weight: 379.461
• Mol file: 213411-02-0.mol

Synonyms:7-[(2,5-diphenyl-3,4-dihydro-2H-pyrazol-3-yl)methyl]quinolin-8-ol

Chemical Property of 7-[(2,5-diphenyl-3,4-dihydro-2H-pyrazol-3-yl)methyl]quinolin-8-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-[(2,5-diphenyl-3,4-dihydro-2H-pyrazol-3-yl)methyl]quinolin-8-ol

There total 3 articles about 7-[(2,5-diphenyl-3,4-dihydro-2H-pyrazol-3-yl)methyl]quinolin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

7-allylquinolin-8-ol (5541-69-5) + α-chlorobenzaldehyde phenylhydrazone (918497-00-4) → 7-[(2,5-diphenyl-3,4-dihydro-2H-pyrazol-3-yl)methyl]quinolin-8-ol (213411-02-0)

Guidance literature:

With triethylamine; In benzene; for 48h; Heating;

DOI:10.1002/jhet.5570400207

Reference yield:

8-quinolinol (148-24-3,24804-14-6) → 7-[(2,5-diphenyl-3,4-dihydro-2H-pyrazol-3-yl)methyl]quinolin-8-ol (213411-02-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / K₂CO₃ / acetone / 24 h / Heating

2: 80 percent / 160 - 200 °C

3: 82 percent / Et₃N / benzene / 48 h / Heating

With potassium carbonate; triethylamine; In acetone; benzene; 2: Claisen rearrangement;

DOI:10.1002/jhet.5570400207

Reference yield:

8-Allyloxy-chinolin (7652-26-8) → 7-[(2,5-diphenyl-3,4-dihydro-2H-pyrazol-3-yl)methyl]quinolin-8-ol (213411-02-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / 160 - 200 °C

2: 82 percent / Et₃N / benzene / 48 h / Heating

With triethylamine; In benzene; 1: Claisen rearrangement;

DOI:10.1002/jhet.5570400207

upstream raw materials:

7-allylquinolin-8-ol

α-chlorobenzaldehyde phenylhydrazone

8-quinolinol

8-Allyloxy-chinolin