2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl 2-(trifluoromethyl)benzenesulfonate

Base Information

Chemical Name:2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl 2-(trifluoromethyl)benzenesulfonate
CAS No.:1345985-95-6
Molecular Formula:C₂₇H₂₈F₃NO₅S
Molecular Weight:535.584
Hs Code.:

Synonyms:2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl 2-(trifluoromethyl)benzenesulfonate

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Chemical Property of 2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl 2-(trifluoromethyl)benzenesulfonate

Chemical Property:

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Technology Process of 2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl 2-(trifluoromethyl)benzenesulfonate

There total 8 articles about 2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl 2-(trifluoromethyl)benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 776-04-5
2-trifluoromethylbenzenesulfonyl chloride

: 215391-96-1
rac-2-(N-tert-Butoxycarbonyl-N-benzylamino)-1-phenylethanol

: 1345985-95-6
2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl 2-(trifluoromethyl)benzenesulfonate

Guidance literature:: rac-2-(N-tert-Butoxycarbonyl-N-benzylamino)-1-phenylethanol; With potassium hydroxide; In tetrahydrofuran; for 0.25h;

2-trifluoromethylbenzenesulfonyl chloride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2011.08.078

Reference yield:

: 96-09-3
styrene oxide

: 1345985-95-6
2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl 2-(trifluoromethyl)benzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: activated silica / 24 h / Inert atmosphere

2: triethylamine / methanol / 0.5 h / Reflux

3: potassium hydroxide / tetrahydrofuran / 0.25 h

With triethylamine; potassium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2011.08.078

Reference yield:

: 51096-49-2,91579-12-3,107171-75-5,27159-30-4
2-benzylamino-1-phenyl-ethanol

: 1345985-95-6
2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl 2-(trifluoromethyl)benzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / methanol / 0.5 h / Reflux

2: potassium hydroxide / tetrahydrofuran / 0.25 h

With triethylamine; potassium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2011.08.078