tert-butyl 4-(4-methyl-3-oxo-1,2,3,4-tetrahydrocyclopenta[b]-indol-7-yl)phenylcarbamate

Base Information

Chemical Name:tert-butyl 4-(4-methyl-3-oxo-1,2,3,4-tetrahydrocyclopenta[b]-indol-7-yl)phenylcarbamate
CAS No.:1600516-00-4
Molecular Formula:C₂₃H₂₄N₂O₃
Molecular Weight:376.455
Hs Code.:

Synonyms:tert-butyl 4-(4-methyl-3-oxo-1,2,3,4-tetrahydrocyclopenta[b]-indol-7-yl)phenylcarbamate

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Chemical Property of tert-butyl 4-(4-methyl-3-oxo-1,2,3,4-tetrahydrocyclopenta[b]-indol-7-yl)phenylcarbamate

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Technology Process of tert-butyl 4-(4-methyl-3-oxo-1,2,3,4-tetrahydrocyclopenta[b]-indol-7-yl)phenylcarbamate

There total 4 articles about tert-butyl 4-(4-methyl-3-oxo-1,2,3,4-tetrahydrocyclopenta[b]-indol-7-yl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1323359-52-9
7-bromo-4-methyl-1,4-dihydro-2H-cyclopenta[b]indol-3-one

: 1600516-00-4
tert-butyl 4-(4-methyl-3-oxo-1,2,3,4-tetrahydrocyclopenta[b]-indol-7-yl)phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tetrahydrofuran / 3.5 h / Reflux; Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2.5 h / Inert atmosphere

3: tetrahydrofuran / Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium 10% on activated carbon; hydrogen; palladium diacetate; In tetrahydrofuran;
DOI:10.1039/c3ob42592d

Reference yield:

: 24067-17-2
4-nitrophenylboronic acid

: 1600516-00-4
tert-butyl 4-(4-methyl-3-oxo-1,2,3,4-tetrahydrocyclopenta[b]-indol-7-yl)phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tetrahydrofuran / 3.5 h / Reflux; Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2.5 h / Inert atmosphere

3: tetrahydrofuran / Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium 10% on activated carbon; hydrogen; palladium diacetate; In tetrahydrofuran;
DOI:10.1039/c3ob42592d

Reference yield:

: 1323359-54-1
4-methyl-7-(4-nitrophenyl)-1,4-dihydro-2H-cyclopenta[b]indol-3-one

: 1600516-00-4
tert-butyl 4-(4-methyl-3-oxo-1,2,3,4-tetrahydrocyclopenta[b]-indol-7-yl)phenylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2.5 h / Inert atmosphere

2: tetrahydrofuran / Reflux

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran;
DOI:10.1039/c3ob42592d