4-((4-(benzylamino)-6-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide

Base Information

• Chemical Name: 4-((4-(benzylamino)-6-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide
• CAS No.: 1236264-74-6
• Molecular Formula: C₃₆H₃₇N₇O
• Molecular Weight: 583.736

Synonyms:4-((4-(benzylamino)-6-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide

Chemical Property of 4-((4-(benzylamino)-6-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide

Chemical Property:

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Technology Process of 4-((4-(benzylamino)-6-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide

There total 7 articles about 4-((4-(benzylamino)-6-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-((4-chloro-6-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide (1236265-89-6) + benzylamine (100-46-9) → 4-((4-(benzylamino)-6-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide (1236264-74-6)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 80 ℃;

Reference yield:

1,2,3,4-tetrahydroisoquinoline (14099-81-1) → 4-((4-(benzylamino)-6-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide (1236264-74-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / acetonitrile; water / 0.33 h / 0 °C / pH 9 - 10

2: sodium hydroxide / acetonitrile; water / 20 °C / pH 9 - 10

3: acetonitrile; water; 1-methyl-pyrrolidin-2-one / 4 h / 80 °C

With sodium hydroxide; In 1-methyl-pyrrolidin-2-one; water; acetonitrile;

DOI:10.1021/acsmedchemlett.5b00138

Reference yield:

2-(4,6-dichloro[1,3,5]triazin-2-yl)-1,2,3,4-tetrahydroisoquinoline (884195-75-9) → 4-((4-(benzylamino)-6-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide (1236264-74-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / acetonitrile; water / 20 °C / pH 9 - 10

2: acetonitrile; water; 1-methyl-pyrrolidin-2-one / 4 h / 80 °C

With sodium hydroxide; In 1-methyl-pyrrolidin-2-one; water; acetonitrile;

DOI:10.1021/acsmedchemlett.5b00138

upstream raw materials:

4-((4-chloro-6-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide

benzylamine

1,2,3,4-tetrahydroisoquinoline

2-(4,6-dichloro[1,3,5]triazin-2-yl)-1,2,3,4-tetrahydroisoquinoline

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