C₁₈H₁₃F₃N₂O₂

Base Information Edit

Chemical Name:C₁₈H₁₃F₃N₂O₂
CAS No.:1374109-28-0
Molecular Formula:C₁₈H₁₃F₃N₂O₂
Molecular Weight:346.309
Hs Code.:
Mol file:1374109-28-0.mol

C<sub>18</sub>H<sub>13</sub>F<sub>3</sub>N<sub>2</sub>O<sub>2</sub>

Synonyms:C₁₈H₁₃F₃N₂O₂

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Chemical Property of C₁₈H₁₃F₃N₂O₂ Edit

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Technology Process of C₁₈H₁₃F₃N₂O₂

There total 6 articles about C₁₈H₁₃F₃N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1374109-27-9
C₁₆H₁₄N₂O

: 407-25-0
trifluoroacetic anhydride

: 1374109-28-0
C₁₈H₁₃F₃N₂O₂

Guidance literature:: With triethylamine; In dichloromethane; for 0.5h; Cooling with ice;

Reference yield:

: 19315-93-6
quinoline-2,6-diol

: 1374109-28-0
C₁₈H₁₃F₃N₂O₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 16 h / 20 °C / Cooling with ice

2.1: pyridinium p-toluenesulfonate / tetrahydrofuran / 2.5 h / 20 °C

3.1: potassium carbonate / water; 1,2-dimethoxyethane / 9 h / 80 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / Cooling with ice; Inert atmosphere

4.2: 0.17 h

5.1: trifluoroacetic acid / chloroform / 1 h / 20 °C / Cooling with ice

6.1: triethylamine / dichloromethane / 0.5 h / Cooling with ice

With thionyl chloride; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 577967-89-6
6-hydroxy-2-chloroquinoline

: 1374109-28-0
C₁₈H₁₃F₃N₂O₂

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridinium p-toluenesulfonate / tetrahydrofuran / 2.5 h / 20 °C

2.1: potassium carbonate / water; 1,2-dimethoxyethane / 9 h / 80 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / Cooling with ice; Inert atmosphere

3.2: 0.17 h

4.1: trifluoroacetic acid / chloroform / 1 h / 20 °C / Cooling with ice

5.1: triethylamine / dichloromethane / 0.5 h / Cooling with ice

With pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; mineral oil;