Technology Process of 4-chloro-7-methoxy-3-(4-methoxyphenyl)isocoumarine
There total 3 articles about 4-chloro-7-methoxy-3-(4-methoxyphenyl)isocoumarine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-methoxy-2-(4-methoxyphenylethynyl)benzoic acid methyl ester;
With
mercury(II) diacetate; acetic acid;
at 20 ℃;
for 1h;
With
copper(l) chloride;
In
tetrahydrofuran;
for 4h;
Heating;
DOI:10.1016/j.bmc.2005.07.014
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 75 percent / triethylamine; CuI; tetrabutylammonium iodide / Pd(PPh3)4 / acetonitrile / 4 h / Heating
2.1: Hg(OAc)2; CH3CO2H / 1 h / 20 °C
2.2: 28 percent / CuCl / tetrahydrofuran / 4 h / Heating
With
copper(l) iodide; mercury(II) diacetate; tetra-(n-butyl)ammonium iodide; acetic acid; triethylamine;
tetrakis(triphenylphosphine) palladium(0);
In
acetonitrile;
1.1: Sonogashira coupling;
DOI:10.1016/j.bmc.2005.07.014
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 90 percent / triethylamine / toluene / 1 h / 20 °C
2.1: 75 percent / triethylamine; CuI; tetrabutylammonium iodide / Pd(PPh3)4 / acetonitrile / 4 h / Heating
3.1: Hg(OAc)2; CH3CO2H / 1 h / 20 °C
3.2: 28 percent / CuCl / tetrahydrofuran / 4 h / Heating
With
copper(l) iodide; mercury(II) diacetate; tetra-(n-butyl)ammonium iodide; acetic acid; triethylamine;
tetrakis(triphenylphosphine) palladium(0);
In
toluene; acetonitrile;
2.1: Sonogashira coupling;
DOI:10.1016/j.bmc.2005.07.014
