(2R)-2-azido-N-benzyl-3-phenylpropionamide

Base Information

Chemical Name:(2R)-2-azido-N-benzyl-3-phenylpropionamide
CAS No.:446253-67-4
Molecular Formula:C₁₆H₁₆N₄O
Molecular Weight:280.329
Hs Code.:

Synonyms:(2R)-2-azido-N-benzyl-3-phenylpropionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-azido-N-benzyl-3-phenylpropionamide

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Technology Process of (2R)-2-azido-N-benzyl-3-phenylpropionamide

There total 7 articles about (2R)-2-azido-N-benzyl-3-phenylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 946534-43-6
C₁₇H₁₉NO₃SO

: 446253-67-4
(2R)-2-azido-N-benzyl-3-phenylpropionamide

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; dmap; sodium azide; 2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-benzopentaoxacyclopentadecin; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.05.044

Reference yield: 92.0%

: 118460-00-7
(R)-2-azido-3-phenylpropionic acid

: 100-46-9
benzylamine

: 446253-67-4
(2R)-2-azido-N-benzyl-3-phenylpropionamide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 3h;
DOI:10.1021/jo025631l

Reference yield:

: 88333-03-3,10340-91-7
Benzyl isocyanide

: 446253-67-4
(2R)-2-azido-N-benzyl-3-phenylpropionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / CH₂Cl₂ / 90 h / 20 °C

2: 50 percent / wheat germ lipase (EC 3.1.1.3); H₂O / diethyl ether / 648 h / 20 °C

3: 94 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

4: 93 percent / NaN₃; 1,4-diazabicyclo[2.2.2]octane; 4-dimethylaminopyridine / benzo-15-crown-5 / H₂O; dimethylformamide

With 1,4-diaza-bicyclo[2.2.2]octane; dmap; sodium azide; water; triethylamine; 2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-benzopentaoxacyclopentadecin; In diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; 1: Passerini reaction;
DOI:10.1016/j.tet.2007.05.044