N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethyl-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-acetamide

Base Information

Chemical Name:N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethyl-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-acetamide
CAS No.:929078-22-8
Molecular Formula:C₃₄H₃₇N₃O₇
Molecular Weight:599.684
Hs Code.:

<i>N</i>-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethyl-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-acetamide

Synonyms:N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethyl-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-acetamide

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Chemical Property of N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethyl-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-acetamide

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Technology Process of N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethyl-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-acetamide

There total 10 articles about N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethyl-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 929078-05-7
N⁴-acetyl-2'-deoxy-2'-C-α-ethylcytidine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 929078-22-8
N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethyl-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-acetamide

Guidance literature:: With pyridine; dmap; at 20 ℃; for 21h;
DOI:10.1021/jo062002t

Reference yield:

: 929078-04-6
N⁴-acetyl-3',5'-O-(di-tert-butylsilanediyl)-2'-deoxy-2'-C-α-ethylcytidine

: 929078-22-8
N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethyl-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / Et₃N*3HF; Et₃N / tetrahydrofuran / 1 h / 20 °C

2: 89 percent / pyridine; 4-(dimethylamino)pyridine / 21 h / 20 °C

With pyridine; dmap; triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran;
DOI:10.1021/jo062002t

Reference yield:

: 929077-99-6
N⁴-acetyl-3',5'-O-(di-tert-butylsilanediyl)-2'-deoxy-2'-C-α-(2-oxoethyl)cytidine

: 929078-22-8
N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethyl-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 31 percent / NaBH₄ / methanol / 0.5 h / 0 °C

2: 74 percent / Ph₃P; imidazole; I₂ / benzene; acetonitrile / 3 h / 20 °C

3: 91 percent / AIBN; n-Bu₃SnH / benzene; tetrahydrofuran / 1 h / 0 °C / ultrasound irradiation

4: 99 percent / Et₃N*3HF; Et₃N / tetrahydrofuran / 1 h / 20 °C

5: 89 percent / pyridine; 4-(dimethylamino)pyridine / 21 h / 20 °C

With pyridine; 1H-imidazole; dmap; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); iodine; tri-n-butyl-tin hydride; triethylamine tris(hydrogen fluoride); triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; acetonitrile; benzene;
DOI:10.1021/jo062002t