Technology Process of (S)-2-[2-(2-methoxyphenyl)-3-methylbut-2-yl]-5,5-tetramethyl-1,3,2-dioxaborinane
There total 1 articles about (S)-2-[2-(2-methoxyphenyl)-3-methylbut-2-yl]-5,5-tetramethyl-1,3,2-dioxaborinane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-(-)-1-(2-methoxyphenyl)ethyl N,N-diisopropylcarbamate;
With
sec.-butyllithium;
In
diethyl ether; hexane; cyclohexane;
at -78 ℃;
for 0.333333h;
5,5-dimethyl-2-(1-methylethyl)-1,3,2-dioxaborinane;
In
diethyl ether; hexane; cyclohexane;
at -78 ℃;
for 1.08333h;
optical yield given as %ee;
Further stages;
DOI:10.1002/anie.201001371
- Guidance literature:
-
With
ethylenediaminetetraacetic acid; dihydrogen peroxide; sodium hydroxide;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
optical yield given as %ee;
Inert atmosphere;
DOI:10.1002/anie.201001371
