Technology Process of 6-O-[2,2-dimethyl-8-(tert-butyldiphenylsilyloxy)-octanoyl]-β-D-galactopyranosyl azide
There total 6 articles about 6-O-[2,2-dimethyl-8-(tert-butyldiphenylsilyloxy)-octanoyl]-β-D-galactopyranosyl azide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 88 percent / imidazole / dimethylformamide / 36 h / 20 °C
2.1: 97 percent / tetrabromomethane; triphenylphosphine / CH2Cl2 / 15 h / 0 - 20 °C
3.1: LDA / tetrahydrofuran; hexane / 2 h / -20 - 50 °C
3.2: 78 percent / tetrahydrofuran; hexane / 1 h / 40 °C
4.1: oxalyl chloride / CH2Cl2 / 20 °C
5.1: 15.90 g / pyridine; DMAP / 20 h / 70 °C
With
pyridine; 1H-imidazole; dmap; oxalyl dichloride; carbon tetrabromide; triphenylphosphine; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.200400253
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 97 percent / tetrabromomethane; triphenylphosphine / CH2Cl2 / 15 h / 0 - 20 °C
2.1: LDA / tetrahydrofuran; hexane / 2 h / -20 - 50 °C
2.2: 78 percent / tetrahydrofuran; hexane / 1 h / 40 °C
3.1: oxalyl chloride / CH2Cl2 / 20 °C
4.1: 15.90 g / pyridine; DMAP / 20 h / 70 °C
With
pyridine; dmap; oxalyl dichloride; carbon tetrabromide; triphenylphosphine; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/chem.200400253
