(R)-3-((2R,3S)-2-((E)-3-methylstyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoic acid

Base Information

Chemical Name:(R)-3-((2R,3S)-2-((E)-3-methylstyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoic acid
CAS No.:1361214-49-4
Molecular Formula:C₃₃H₃₃N₃O₆
Molecular Weight:567.642
Hs Code.:

Synonyms:(R)-3-((2R,3S)-2-((E)-3-methylstyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoic acid

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Chemical Property of (R)-3-((2R,3S)-2-((E)-3-methylstyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoic acid

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Technology Process of (R)-3-((2R,3S)-2-((E)-3-methylstyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoic acid

There total 11 articles about (R)-3-((2R,3S)-2-((E)-3-methylstyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1361214-46-1
(R)-tert-butyl 3-((2R,3S)-2-((E)-3-methylstyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoate

: 1361214-49-4
(R)-3-((2R,3S)-2-((E)-3-methylstyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoic acid

Guidance literature:: With formic acid; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2011.12.013

Reference yield:

: 512785-11-4
N-[(benzyloxy)carbonyl]-D-aspartic acid β-tert-butyl ester α-[(R)-α-methylbenzyl]amide

: 1361214-49-4
(R)-3-((2R,3S)-2-((E)-3-methylstyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 5%-palladium/activated carbon; hydrogen / methanol / 18 h

2: dichloromethane / 20 °C / desiccating agent

3: triethylamine / dichloromethane / 1 h / 0 - 20 °C

4: formic acid / 3 h / 20 °C

With formic acid; 5%-palladium/activated carbon; hydrogen; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2011.12.013

Reference yield:

: 512785-16-9
D-aspartic acid β-tert-butyl ester α-[(R)-α-methylbenzyl]amide

: 1361214-49-4
(R)-3-((2R,3S)-2-((E)-3-methylstyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 20 °C / desiccating agent

2: triethylamine / dichloromethane / 1 h / 0 - 20 °C

3: formic acid / 3 h / 20 °C

With formic acid; triethylamine; In dichloromethane;
DOI:10.1016/j.bmc.2011.12.013