(2S,3S)-2-Benzyloxycarbonylamino-3-cyclopropyl-butyric acid benzyl ester

Base Information

Chemical Name:(2S,3S)-2-Benzyloxycarbonylamino-3-cyclopropyl-butyric acid benzyl ester
CAS No.:416898-40-3
Molecular Formula:C₂₂H₂₅NO₄
Molecular Weight:367.445
Hs Code.:

Synonyms:(2S,3S)-2-Benzyloxycarbonylamino-3-cyclopropyl-butyric acid benzyl ester

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Chemical Property of (2S,3S)-2-Benzyloxycarbonylamino-3-cyclopropyl-butyric acid benzyl ester

Chemical Property:

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Technology Process of (2S,3S)-2-Benzyloxycarbonylamino-3-cyclopropyl-butyric acid benzyl ester

There total 6 articles about (2S,3S)-2-Benzyloxycarbonylamino-3-cyclopropyl-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 416898-39-0
(2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pent-4-enoic acid benzyl ester

: 416898-40-3
(2S,3S)-2-Benzyloxycarbonylamino-3-cyclopropyl-butyric acid benzyl ester

Guidance literature:: palladium diacetate; In diethyl ether; at 0 ℃; for 1h;
DOI:10.1039/b108752e

Reference yield:

: 416898-38-9
(2S,3S)-2-(benzyloxycarbonylamino)-3-methylpent-4-enoic acid

: 416898-40-3
(2S,3S)-2-Benzyloxycarbonylamino-3-cyclopropyl-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / EDCl; DMAP / CH₂Cl₂ / 4 h / 20 °C

2: 100 percent / Pd(OAc)2 / diethyl ether / 1 h / 0 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium diacetate; In diethyl ether; dichloromethane;
DOI:10.1039/b108752e

Reference yield:

: 416898-36-7
(S)-(Z)-1-(tert-butyldimethylsilyl)-2-butenyl N-tert-butyloxycarbonylglycinate

: 416898-40-3
(2S,3S)-2-Benzyloxycarbonylamino-3-cyclopropyl-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / LDA; ZnCl₂ / tetrahydrofuran / 2 h / -78 - 20 °C

2: 100 percent / aq. HBF₄ / dioxane / 14 h / 65 °C

3: 73 percent / aq. K₂CO₃ / dioxane / 12 h / 0 - 20 °C

4: 94 percent / EDCl; DMAP / CH₂Cl₂ / 4 h / 20 °C

5: 100 percent / Pd(OAc)2 / diethyl ether / 1 h / 0 °C

With dmap; tetrafluoroboric acid; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc(II) chloride; lithium diisopropyl amide; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1039/b108752e