2-(((S)-1-(8-chloro-2-(2-fluoro-phenyl)quinolin-3-yl)ethyl)carbamoyl)benzoic acid

Base Information

Chemical Name:2-(((S)-1-(8-chloro-2-(2-fluoro-phenyl)quinolin-3-yl)ethyl)carbamoyl)benzoic acid
CAS No.:1065481-76-6
Molecular Formula:C₂₅H₁₈ClFN₂O₃
Molecular Weight:448.881
Hs Code.:

Synonyms:2-(((S)-1-(8-chloro-2-(2-fluoro-phenyl)quinolin-3-yl)ethyl)carbamoyl)benzoic acid

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Chemical Property of 2-(((S)-1-(8-chloro-2-(2-fluoro-phenyl)quinolin-3-yl)ethyl)carbamoyl)benzoic acid

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Technology Process of 2-(((S)-1-(8-chloro-2-(2-fluoro-phenyl)quinolin-3-yl)ethyl)carbamoyl)benzoic acid

There total 6 articles about 2-(((S)-1-(8-chloro-2-(2-fluoro-phenyl)quinolin-3-yl)ethyl)carbamoyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1065481-12-0
(S)-2-(1-(2,8-dichloroquinolin-3-yl)ethyl)isoindoline-1,3-dione

: 1993-03-9
o-fluorophenylboronic acid

: 1065481-76-6
2-(((S)-1-(8-chloro-2-(2-fluoro-phenyl)quinolin-3-yl)ethyl)carbamoyl)benzoic acid

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; acetonitrile; at 85 ℃; for 28h;

Reference yield:

: 136918-14-4,85-41-6
phthalimide

: 1065481-76-6
2-(((S)-1-(8-chloro-2-(2-fluoro-phenyl)quinolin-3-yl)ethyl)carbamoyl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / 28 h / 85 °C

With di-isopropyl azodicarboxylate; sodium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; acetonitrile;

Reference yield:

: 4470-83-1
2,8-dichloroquinoline

: 1065481-76-6
2-(((S)-1-(8-chloro-2-(2-fluoro-phenyl)quinolin-3-yl)ethyl)carbamoyl)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -78 - 0 °C

1.2: 4 h / -78 °C

2.1: manganese(IV) oxide / toluene / 2 h / Heating / reflux

3.1: B-chlorodiisopinocampheylborane / tetrahydrofuran / -78 - 20 °C

3.2: 20 °C

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / 28 h / 85 °C

With manganese(IV) oxide; n-butyllithium; di-isopropyl azodicarboxylate; sodium carbonate; diisopropylamine; triphenylphosphine; B-chlorodiisopinocampheylborane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; water; toluene; acetonitrile;