[2-Amino-4-(4-{5-amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butoxy)-5-methoxy-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone

Base Information

Chemical Name:[2-Amino-4-(4-{5-amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butoxy)-5-methoxy-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone
CAS No.:808154-89-4
Molecular Formula:C₄₀H₅₄F₄N₄O₆S₄
Molecular Weight:891.15
Hs Code.:

[2-Amino-4-(4-{5-amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butoxy)-5-methoxy-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone

Synonyms:[2-Amino-4-(4-{5-amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butoxy)-5-methoxy-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone

Suppliers and Price of [2-Amino-4-(4-{5-amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butoxy)-5-methoxy-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [2-Amino-4-(4-{5-amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butoxy)-5-methoxy-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [2-Amino-4-(4-{5-amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butoxy)-5-methoxy-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone

There total 11 articles about [2-Amino-4-(4-{5-amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butoxy)-5-methoxy-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 808154-89-4
[2-Amino-4-(4-{5-amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butoxy)-5-methoxy-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 10 steps

1: 100 percent / aq. NaOH / tetrahydrofuran / 20 °C

2: trichloroisocyanuric acid; TEMPO / CH₂Cl₂

3: HMPT; Zn / tetrahydrofuran

4: TFA / CH₂Cl₂

5: Et₃N / dimethylformamide; tetrahydrofuran

6: 85 percent / DIBAL-H / CH₂Cl₂ / 0.75 h / -78 °C

7: 90 percent / TMSCl / CHCl₃ / 24 h / 20 °C

8: 80 percent / EtSH-BF₃OEt₂ / CH₂Cl₂ / 12 h / 20 °C

9: K₂CO₃ / acetone / Heating

10: SnCl₂*2H₂O / methanol / 2 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydroxide; chloro-trimethyl-silane; trichloroisocyanuric acid; boron trifluoride diethyl etherate; diisobutylaluminium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; ethanethiol; tin(ll) chloride; zinc; In tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2004.08.050

Reference yield:

: 64154-78-5
4-benzyloxy-5-methoxy-2-nitrobenzoyl chloride

: 808154-89-4
[2-Amino-4-(4-{5-amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butoxy)-5-methoxy-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / dimethylformamide; tetrahydrofuran

2: 85 percent / DIBAL-H / CH₂Cl₂ / 0.75 h / -78 °C

3: 90 percent / TMSCl / CHCl₃ / 24 h / 20 °C

4: 80 percent / EtSH-BF₃OEt₂ / CH₂Cl₂ / 12 h / 20 °C

5: K₂CO₃ / acetone / Heating

6: SnCl₂*2H₂O / methanol / 2 h / Heating

With chloro-trimethyl-silane; boron trifluoride diethyl etherate; diisobutylaluminium hydride; potassium carbonate; triethylamine; ethanethiol; tin(ll) chloride; In tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2004.08.050

Reference yield:

: 60547-92-4
4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid

: 808154-89-4
[2-Amino-4-(4-{5-amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butoxy)-5-methoxy-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 7 steps

1: (COCl)2; DMF / tetrahydrofuran

2: Et₃N / dimethylformamide; tetrahydrofuran

3: 85 percent / DIBAL-H / CH₂Cl₂ / 0.75 h / -78 °C

4: 90 percent / TMSCl / CHCl₃ / 24 h / 20 °C

5: 80 percent / EtSH-BF₃OEt₂ / CH₂Cl₂ / 12 h / 20 °C

6: K₂CO₃ / acetone / Heating

7: SnCl₂*2H₂O / methanol / 2 h / Heating

With chloro-trimethyl-silane; oxalyl dichloride; boron trifluoride diethyl etherate; diisobutylaluminium hydride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; ethanethiol; tin(ll) chloride; In tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2004.08.050