Technology Process of 3β-(tert-butyldiphenylsiloxy)-12β-acetyl-14β-hydroxy-5β,14β-pregn-20-one
There total 4 articles about 3β-(tert-butyldiphenylsiloxy)-12β-acetyl-14β-hydroxy-5β,14β-pregn-20-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3β-(tert-butyldiphenylsiloxy)-12β-acetyl-14β-hydroxy-5β,14β-card-20(22)-enolide;
With
ozone;
In
dichloromethane;
at -60 ℃;
Inert atmosphere;
With
acetic acid; zinc;
at 80 ℃;
for 3h;
Inert atmosphere;
DOI:10.1039/c2cc34404a
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: pyridine / 3 h / 20 - 80 °C / Inert atmosphere
2.1: sulfuric acid / methanol; water / 1 h / Reflux; Inert atmosphere
3.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
4.1: ozone / dichloromethane / -60 °C / Inert atmosphere
4.2: 3 h / 80 °C / Inert atmosphere
With
pyridine; 1H-imidazole; sulfuric acid; ozone;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c2cc34404a
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sulfuric acid / methanol; water / 1 h / Reflux; Inert atmosphere
2.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
3.1: ozone / dichloromethane / -60 °C / Inert atmosphere
3.2: 3 h / 80 °C / Inert atmosphere
With
1H-imidazole; sulfuric acid; ozone;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c2cc34404a
