3β-(tert-butyldiphenylsiloxy)-12β-acetyl-14β-hydroxy-5β,14β-pregn-20-one

Base Information

Chemical Name:3β-(tert-butyldiphenylsiloxy)-12β-acetyl-14β-hydroxy-5β,14β-pregn-20-one
CAS No.:1393730-34-1
Molecular Formula:C₃₉H₅₄O₅Si
Molecular Weight:630.94
Hs Code.:

Synonyms:3β-(tert-butyldiphenylsiloxy)-12β-acetyl-14β-hydroxy-5β,14β-pregn-20-one

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Chemical Property of 3β-(tert-butyldiphenylsiloxy)-12β-acetyl-14β-hydroxy-5β,14β-pregn-20-one

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Technology Process of 3β-(tert-butyldiphenylsiloxy)-12β-acetyl-14β-hydroxy-5β,14β-pregn-20-one

There total 4 articles about 3β-(tert-butyldiphenylsiloxy)-12β-acetyl-14β-hydroxy-5β,14β-pregn-20-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1393730-33-0
3β-(tert-butyldiphenylsiloxy)-12β-acetyl-14β-hydroxy-5β,14β-card-20(22)-enolide

: 1393730-34-1
3β-(tert-butyldiphenylsiloxy)-12β-acetyl-14β-hydroxy-5β,14β-pregn-20-one

Guidance literature:: 3β-(tert-butyldiphenylsiloxy)-12β-acetyl-14β-hydroxy-5β,14β-card-20(22)-enolide; With ozone; In dichloromethane; at -60 ℃; Inert atmosphere;

With acetic acid; zinc; at 80 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c2cc34404a

Reference yield:

: 20830-75-5
digoxin

: 1393730-34-1
3β-(tert-butyldiphenylsiloxy)-12β-acetyl-14β-hydroxy-5β,14β-pregn-20-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 3 h / 20 - 80 °C / Inert atmosphere

2.1: sulfuric acid / methanol; water / 1 h / Reflux; Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.1: ozone / dichloromethane / -60 °C / Inert atmosphere

4.2: 3 h / 80 °C / Inert atmosphere

With pyridine; 1H-imidazole; sulfuric acid; ozone; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c2cc34404a

Reference yield:

: 26707-62-0,67467-55-4
(+)-12,3'a,3'b,3'c,4'c-penta-O-acetyldigoxin

: 1393730-34-1
3β-(tert-butyldiphenylsiloxy)-12β-acetyl-14β-hydroxy-5β,14β-pregn-20-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / methanol; water / 1 h / Reflux; Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.1: ozone / dichloromethane / -60 °C / Inert atmosphere

3.2: 3 h / 80 °C / Inert atmosphere

With 1H-imidazole; sulfuric acid; ozone; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c2cc34404a