Technology Process of C18H18Br3N5O3
There total 9 articles about C18H18Br3N5O3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 8 steps
1.1: bromine; copper(ll) bromide / acetonitrile / 1 h / 50 °C
1.2: 0.5 h
2.1: sodium azide / N,N-dimethyl-formamide
3.1: sodium hydroxide / ethanol / 3 h / 85 °C
4.1: tert.-butylnitrite / tetrahydrofuran / 3 h / 50 °C
5.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 2 h / 20 °C
6.1: hydroxylamine hydrochloride; potassium carbonate / ethanol / 16 h / 20 °C
7.1: pyridine / 20 h / 90 °C
8.1: methanol; sodium hydroxide / tetrahydrofuran / 3 h / 20 °C
With
pyridine; methanol; sodium azide; tert.-butylnitrite; hydroxylamine hydrochloride; bromine; potassium carbonate; triethylamine; trifluoroacetic anhydride; sodium hydroxide; copper(ll) bromide;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2011.08.073
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium hydroxide / ethanol / 3 h / 85 °C
2: tert.-butylnitrite / tetrahydrofuran / 3 h / 50 °C
3: triethylamine; trifluoroacetic anhydride / dichloromethane / 2 h / 20 °C
4: hydroxylamine hydrochloride; potassium carbonate / ethanol / 16 h / 20 °C
5: pyridine / 20 h / 90 °C
6: methanol; sodium hydroxide / tetrahydrofuran / 3 h / 20 °C
With
pyridine; methanol; tert.-butylnitrite; hydroxylamine hydrochloride; potassium carbonate; triethylamine; trifluoroacetic anhydride; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.08.073