methyl 4-{3-[(4-methylphenyl)sulfonyl]-1-phenyl-3-azabicyclo[4.1.0]hept-4-en-6-yl}benzoate

Base Information

Chemical Name:methyl 4-{3-[(4-methylphenyl)sulfonyl]-1-phenyl-3-azabicyclo[4.1.0]hept-4-en-6-yl}benzoate
CAS No.:1451188-29-6
Molecular Formula:C₂₇H₂₅NO₄S
Molecular Weight:459.566
Hs Code.:

Synonyms:methyl 4-{3-[(4-methylphenyl)sulfonyl]-1-phenyl-3-azabicyclo[4.1.0]hept-4-en-6-yl}benzoate

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Chemical Property of methyl 4-{3-[(4-methylphenyl)sulfonyl]-1-phenyl-3-azabicyclo[4.1.0]hept-4-en-6-yl}benzoate

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Technology Process of methyl 4-{3-[(4-methylphenyl)sulfonyl]-1-phenyl-3-azabicyclo[4.1.0]hept-4-en-6-yl}benzoate

There total 4 articles about methyl 4-{3-[(4-methylphenyl)sulfonyl]-1-phenyl-3-azabicyclo[4.1.0]hept-4-en-6-yl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1451188-12-7
methyl 4-{3-[[(4-methylphenyl)sulfonyl](2-phenylprop-2-en-1-yl)amino]prop-1-yn-1-yl}benzoate

: 1451188-29-6
methyl 4-{3-[(4-methylphenyl)sulfonyl]-1-phenyl-3-azabicyclo[4.1.0]hept-4-en-6-yl}benzoate

Guidance literature:: With platinum(II) chloride; In toluene; at 80 ℃; for 2h;
DOI:10.1002/chem.201202647

Reference yield:

: 55022-46-3
4-methyl-N-prop-2-ynylbenzenesulfonamide

: 1451188-29-6
methyl 4-{3-[(4-methylphenyl)sulfonyl]-1-phenyl-3-azabicyclo[4.1.0]hept-4-en-6-yl}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; triethylamine; copper(l) iodide; palladium diacetate / N,N-dimethyl-formamide / 14 h

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; potassium carbonate / acetonitrile / 24 h / 80 °C / 375.04 Torr / Schlenk technique; Sealed tube

3: platinum(II) chloride / toluene / 2 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; trifuran-2-yl-phosphane; palladium diacetate; potassium carbonate; triethylamine; triphenylphosphine; platinum(II) chloride; In N,N-dimethyl-formamide; toluene; acetonitrile; 1: |Sonogashira Cross-Coupling;
DOI:10.1002/chem.201202647

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1451188-29-6
methyl 4-{3-[(4-methylphenyl)sulfonyl]-1-phenyl-3-azabicyclo[4.1.0]hept-4-en-6-yl}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 15 h / 20 °C / Cooling with ice

2: triphenylphosphine; triethylamine; copper(l) iodide; palladium diacetate / N,N-dimethyl-formamide / 14 h

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; potassium carbonate / acetonitrile / 24 h / 80 °C / 375.04 Torr / Schlenk technique; Sealed tube

4: platinum(II) chloride / toluene / 2 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; trifuran-2-yl-phosphane; palladium diacetate; potassium carbonate; triethylamine; triphenylphosphine; platinum(II) chloride; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 2: |Sonogashira Cross-Coupling;
DOI:10.1002/chem.201202647