(S)-3-((S)-1-benzyl-2-hydroxy ethyl)-2,4-dioxo-1,3-diazabicyclo[3.3.0]octane

Base Information

Chemical Name:(S)-3-((S)-1-benzyl-2-hydroxy ethyl)-2,4-dioxo-1,3-diazabicyclo[3.3.0]octane
CAS No.:1260507-58-1
Molecular Formula:C₁₅H₁₈N₂O₃
Molecular Weight:274.32
Hs Code.:

Synonyms:(S)-3-((S)-1-benzyl-2-hydroxy ethyl)-2,4-dioxo-1,3-diazabicyclo[3.3.0]octane

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Chemical Property of (S)-3-((S)-1-benzyl-2-hydroxy ethyl)-2,4-dioxo-1,3-diazabicyclo[3.3.0]octane

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Technology Process of (S)-3-((S)-1-benzyl-2-hydroxy ethyl)-2,4-dioxo-1,3-diazabicyclo[3.3.0]octane

There total 3 articles about (S)-3-((S)-1-benzyl-2-hydroxy ethyl)-2,4-dioxo-1,3-diazabicyclo[3.3.0]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1260507-57-0
tert-butyl (S)-2-[(S)-4-benzyl-2-oxo-1,3-oxazolidin-3-ylcarbonyl]pyrrolidine-1-carboxylate

: 1260507-58-1
(S)-3-((S)-1-benzyl-2-hydroxy ethyl)-2,4-dioxo-1,3-diazabicyclo[3.3.0]octane

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; at 0 - 20 ℃; for 8h;
DOI:10.1021/ol102613z

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1260507-58-1
(S)-3-((S)-1-benzyl-2-hydroxy ethyl)-2,4-dioxo-1,3-diazabicyclo[3.3.0]octane

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; water / 8 h / 0 - 20 °C

With hydrogenchloride; dmap; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/ol102613z

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 1260507-58-1
(S)-3-((S)-1-benzyl-2-hydroxy ethyl)-2,4-dioxo-1,3-diazabicyclo[3.3.0]octane

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / tetrahydrofuran; water / 19 h / 20 °C / Cooling with ice

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane; water / 8 h / 0 - 20 °C

With hydrogenchloride; dmap; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1021/ol102613z