Technology Process of 3-benzyl-1-(2-bromobenzyl)-2,3-dihydro-1H-indole
There total 3 articles about 3-benzyl-1-(2-bromobenzyl)-2,3-dihydro-1H-indole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-benzyl-1-(2-bromobenzyl)indolin-2-one;
With
aluminium hydride;
In
toluene;
at -78 - 20 ℃;
for 4.33333h;
Inert atmosphere;
With
hydrogenchloride;
In
methanol; water; toluene;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
DOI:10.1039/c1ob05527e
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogenchloride; acetic acid; zinc / water / 16 h / Inert atmosphere
2.1: aluminium hydride / toluene / 4.33 h / -78 - 20 °C / Inert atmosphere
2.2: 0.17 h / 0 °C / Inert atmosphere
With
aluminium hydride; hydrogenchloride; acetic acid; zinc;
In
water; toluene;
DOI:10.1039/c1ob05527e
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / Inert atmosphere
1.2: 16 h / Inert atmosphere
2.1: hydrogenchloride; acetic acid; zinc / water / 16 h / Inert atmosphere
3.1: aluminium hydride / toluene / 4.33 h / -78 - 20 °C / Inert atmosphere
3.2: 0.17 h / 0 °C / Inert atmosphere
With
aluminium hydride; hydrogenchloride; sodium hydride; acetic acid; zinc;
In
water; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1039/c1ob05527e
