(2S,5S)-2-[2′-(tert-butyldiphenylsilyloxy)ethyl]-5-[(4-fluorophenoxy)methyl]tetrahydrofuran

Base Information Edit

Chemical Name:(2S,5S)-2-[2′-(tert-butyldiphenylsilyloxy)ethyl]-5-[(4-fluorophenoxy)methyl]tetrahydrofuran
CAS No.:1449521-34-9
Molecular Formula:C₂₉H₃₅FO₃Si
Molecular Weight:478.679
Hs Code.:
Mol file:1449521-34-9.mol

Synonyms:(2S,5S)-2-[2′-(tert-butyldiphenylsilyloxy)ethyl]-5-[(4-fluorophenoxy)methyl]tetrahydrofuran

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Chemical Property of (2S,5S)-2-[2′-(tert-butyldiphenylsilyloxy)ethyl]-5-[(4-fluorophenoxy)methyl]tetrahydrofuran Edit

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Technology Process of (2S,5S)-2-[2′-(tert-butyldiphenylsilyloxy)ethyl]-5-[(4-fluorophenoxy)methyl]tetrahydrofuran

There total 2 articles about (2S,5S)-2-[2′-(tert-butyldiphenylsilyloxy)ethyl]-5-[(4-fluorophenoxy)methyl]tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1449521-33-8
O-(2R,3R,5S)-2-[2'-(tert-butyldiphenylsilyloxy)ethyl]-5-[(p-fluorophenoxy)methyl]tetrahydrofuran-3-yl-1H-imidazole-1-carbothioate

: 1449521-34-9
(2S,5S)-2-[2′-(tert-butyldiphenylsilyloxy)ethyl]-5-[(4-fluorophenoxy)methyl]tetrahydrofuran

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 120 ℃; for 3h;
DOI:10.1055/s-0033-1338934

Reference yield:

: 1263497-40-0
C₂₉H₃₅FO₄Si

: 1449521-34-9
(2S,5S)-2-[2′-(tert-butyldiphenylsilyloxy)ethyl]-5-[(4-fluorophenoxy)methyl]tetrahydrofuran

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 24 h / 70 °C

2: tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) / toluene / 3 h / 120 °C

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In tetrahydrofuran; toluene;
DOI:10.1055/s-0033-1338934