[6-fluoro-4-(4-methanesulfonyl-benzyl)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester

Base Information

Chemical Name:[6-fluoro-4-(4-methanesulfonyl-benzyl)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester
CAS No.:1227370-84-4
Molecular Formula:C₂₂H₂₁FO₄S
Molecular Weight:400.471
Hs Code.:

Synonyms:[6-fluoro-4-(4-methanesulfonyl-benzyl)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester

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Chemical Property of [6-fluoro-4-(4-methanesulfonyl-benzyl)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester

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Technology Process of [6-fluoro-4-(4-methanesulfonyl-benzyl)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester

There total 8 articles about [6-fluoro-4-(4-methanesulfonyl-benzyl)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1227259-08-6
(6-fluoro-3-methyl-4-trifluoromethanesulfonyloxy-naphthalen-2-yl)-acetic acid methyl ester

: C₈H₉ClO₂SZn

: 1227370-84-4
[6-fluoro-4-(4-methanesulfonyl-benzyl)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester

Guidance literature:: (6-fluoro-3-methyl-4-trifluoromethanesulfonyloxy-naphthalen-2-yl)-acetic acid methyl ester; With 2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl; palladium diacetate; In tetrahydrofuran; at 20 ℃; Inert atmosphere of nitrogen;

C₈H₉ClO₂SZn; In tetrahydrofuran; at 20 - 60 ℃;

Reference yield:

: 1227258-98-1
4-benzyloxy-6-fluoro-3-methyl-naphthalene-2-carboxylic acid methyl ester

: 1227370-84-4
[6-fluoro-4-(4-methanesulfonyl-benzyl)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride

2.1: triphenylphosphine / tetrachloromethane

3.1: bis(triphenylphosphine)palladium(II) dichloride

4.1: hydrogen; palladium 10% on activated carbon

5.1: pyridine / dichloromethane

6.1: chloro-trimethyl-silane; zinc; lithium chloride / tetrahydrofuran; ethylene dibromide / Large scale

6.2: Large scale

With pyridine; lithium aluminium tetrahydride; chloro-trimethyl-silane; bis(triphenylphosphine)palladium(II) dichloride; palladium 10% on activated carbon; hydrogen; triphenylphosphine; lithium chloride; zinc; In tetrahydrofuran; tetrachloromethane; dichloromethane; ethylene dibromide; 6.2: |Negishi Coupling;
DOI:10.1021/op300306c

Reference yield:

: 1227259-00-8
(4-benzyloxy-6-fluoro-3-methyl-naphthalen-2-yl)-methanol

: 1227370-84-4
[6-fluoro-4-(4-methanesulfonyl-benzyl)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine / tetrachloromethane

2.1: bis(triphenylphosphine)palladium(II) dichloride

3.1: hydrogen; palladium 10% on activated carbon

4.1: pyridine / dichloromethane

5.1: chloro-trimethyl-silane; zinc; lithium chloride / tetrahydrofuran; ethylene dibromide / Large scale

5.2: Large scale

With pyridine; chloro-trimethyl-silane; bis(triphenylphosphine)palladium(II) dichloride; palladium 10% on activated carbon; hydrogen; triphenylphosphine; lithium chloride; zinc; In tetrahydrofuran; tetrachloromethane; dichloromethane; ethylene dibromide; 5.2: |Negishi Coupling;
DOI:10.1021/op300306c