N-((N-⁴-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycine

Base Information

Chemical Name:N-((N-⁴-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycine
CAS No.:144564-94-3
Molecular Formula:C₂₃H₂₉N₅O₈
Molecular Weight:503.512
Hs Code.:

N-((N-<sup>4</sup>-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycine

Synonyms:N-((N-⁴-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycine

Suppliers and Price of N-((N-⁴-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of N-((N-⁴-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-((N-⁴-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycine

There total 6 articles about N-((N-⁴-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 938175-07-6
ethyl N-((N-⁴-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycinate

: 144564-94-3
N-((N-⁴-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycine

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 0 ℃; for 0.25h;
DOI:10.1021/jo00098a042

Reference yield:

: 149411-91-6
N-benzyloxycarbonyl cytosine

: 144564-94-3
N-((N-⁴-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycine

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide

2: aq. NaOH / 0.5 h

3: 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine, DCC / dimethylformamide; CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) r.t., 1 h

4: 69 percent / 1 M aq. LiOH / tetrahydrofuran / 0.25 h / 0 °C

With lithium hydroxide; sodium hydroxide; potassium carbonate; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00098a042

Reference yield:

: 144564-95-4
[N⁴-[(benzyloxy)carbonyl]cytosine-1-yl]acetic acid

: 144564-94-3
N-((N-⁴-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycine

Guidance literature:: Multi-step reaction with 2 steps

1: 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine, DCC / dimethylformamide; CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) r.t., 1 h

2: 69 percent / 1 M aq. LiOH / tetrahydrofuran / 0.25 h / 0 °C

With lithium hydroxide; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00098a042