3-fluoro-6-ethyl-N-(1-ethylpropyl)-5-(2,4-dichlorophenyl)pyrazin-2-amine

Base Information

Chemical Name:3-fluoro-6-ethyl-N-(1-ethylpropyl)-5-(2,4-dichlorophenyl)pyrazin-2-amine
CAS No.:355835-15-3
Molecular Formula:C₁₇H₂₀Cl₂FN₃
Molecular Weight:356.27
Hs Code.:

Synonyms:3-fluoro-6-ethyl-N-(1-ethylpropyl)-5-(2,4-dichlorophenyl)pyrazin-2-amine

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Chemical Property of 3-fluoro-6-ethyl-N-(1-ethylpropyl)-5-(2,4-dichlorophenyl)pyrazin-2-amine

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Technology Process of 3-fluoro-6-ethyl-N-(1-ethylpropyl)-5-(2,4-dichlorophenyl)pyrazin-2-amine

There total 5 articles about 3-fluoro-6-ethyl-N-(1-ethylpropyl)-5-(2,4-dichlorophenyl)pyrazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 355835-13-1
5-(2,4-dichlorophenyl)-6-ethyl-[N-(1-ethyl)propyl]pyrazine-2-amine

: 355835-15-3
3-fluoro-6-ethyl-N-(1-ethylpropyl)-5-(2,4-dichlorophenyl)pyrazin-2-amine

Guidance literature:: With Selectfluor; In chloroform; at 0 - 20 ℃; for 4h;
DOI:10.1021/jm200365y

Reference yield:

: 355836-15-6
6-chloro-[N-(1-ethyl)propyl]pyrazine-2-amine

: 355835-15-3
3-fluoro-6-ethyl-N-(1-ethylpropyl)-5-(2,4-dichlorophenyl)pyrazin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) / tetrahydrofuran / 6 h / 10 - 15 °C

2: N-Bromosuccinimide / chloroform / 1 h / 0 - 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 12 h / 20 - 90 °C / Inert atmosphere

4: Selectfluor / chloroform / 4 h / 0 - 20 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); sodium carbonate; Selectfluor; In tetrahydrofuran; 1,2-dimethoxyethane; chloroform; water; 1: Kumada coupling reaction / 3: Suzuki coupling;
DOI:10.1021/jm200365y

Reference yield:

: 1100873-11-7
N-(1-ethyl)propyl-6-ethylpyrazine-2-amine

: 355835-15-3
3-fluoro-6-ethyl-N-(1-ethylpropyl)-5-(2,4-dichlorophenyl)pyrazin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / chloroform / 1 h / 0 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 12 h / 20 - 90 °C / Inert atmosphere

3: Selectfluor / chloroform / 4 h / 0 - 20 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; Selectfluor; In 1,2-dimethoxyethane; chloroform; water; 2: Suzuki coupling;
DOI:10.1021/jm200365y