1,2-dideoxy-3,4,5,6-di-O-isopropylidene-1-phenyl-2-[(9-phenyl-9-fluorenyl)-amino]-D-gulitol

Base Information

Chemical Name:1,2-dideoxy-3,4,5,6-di-O-isopropylidene-1-phenyl-2-[(9-phenyl-9-fluorenyl)-amino]-D-gulitol
CAS No.:577978-99-5
Molecular Formula:C₃₇H₃₉NO₄
Molecular Weight:561.721
Hs Code.:

Synonyms:1,2-dideoxy-3,4,5,6-di-O-isopropylidene-1-phenyl-2-[(9-phenyl-9-fluorenyl)-amino]-D-gulitol

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Chemical Property of 1,2-dideoxy-3,4,5,6-di-O-isopropylidene-1-phenyl-2-[(9-phenyl-9-fluorenyl)-amino]-D-gulitol

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Technology Process of 1,2-dideoxy-3,4,5,6-di-O-isopropylidene-1-phenyl-2-[(9-phenyl-9-fluorenyl)-amino]-D-gulitol

There total 10 articles about 1,2-dideoxy-3,4,5,6-di-O-isopropylidene-1-phenyl-2-[(9-phenyl-9-fluorenyl)-amino]-D-gulitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 55135-66-5
9-bromo-9-phenyl-9H-fluorene

: 577978-98-4
(S)-2-Phenyl-1-((4R,5S,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-ethylamine

: 577978-99-5
1,2-dideoxy-3,4,5,6-di-O-isopropylidene-1-phenyl-2-[(9-phenyl-9-fluorenyl)-amino]-D-gulitol

Guidance literature:: With lead(II) nitrate; triethylamine; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: phenylmagnesium bromide

: 577978-99-5
1,2-dideoxy-3,4,5,6-di-O-isopropylidene-1-phenyl-2-[(9-phenyl-9-fluorenyl)-amino]-D-gulitol

Guidance literature:: Multi-step reaction with 5 steps

1: 1.10 g / CuI / tetrahydrofuran / 1 h / -40 °C

2: 1.45 g / pyridine / CH₂Cl₂ / 0.17 h / -10 °C

3: NaN₃ / dimethylformamide / 3 h / 20 °C

4: 1.00 g / H₂ / 10 percent Pd/C / ethyl acetate / 20 °C

5: 73 percent / Pb(NO₃)2; Et₃N / CH₂Cl₂ / 24 h / 20 °C

With pyridine; copper(l) iodide; sodium azide; lead(II) nitrate; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1: Grignard reaction;

Reference yield:

: 6322-07-2
D-gulono-1,4-lactone

: 577978-99-5
1,2-dideoxy-3,4,5,6-di-O-isopropylidene-1-phenyl-2-[(9-phenyl-9-fluorenyl)-amino]-D-gulitol

Guidance literature:: Multi-step reaction with 9 steps

1.1: TsOH / acetone; methanol / 2 h / 20 °C

1.2: 95 percent / NaBH₄ / ethanol / 3 h / Heating

2.1: 96 percent / imidazole / CH₂Cl₂ / 1 h / 20 °C

3.1: 97 percent / Et₃N / tetrahydrofuran / 0.33 h / 20 °C

4.1: 89 percent / Bu₄NF / tetrahydrofuran / 3 h / 20 °C

5.1: 1.10 g / CuI / tetrahydrofuran / 1 h / -40 °C

6.1: 1.45 g / pyridine / CH₂Cl₂ / 0.17 h / -10 °C

7.1: NaN₃ / dimethylformamide / 3 h / 20 °C

8.1: 1.00 g / H₂ / 10 percent Pd/C / ethyl acetate / 20 °C

9.1: 73 percent / Pb(NO₃)2; Et₃N / CH₂Cl₂ / 24 h / 20 °C

With pyridine; 1H-imidazole; copper(l) iodide; sodium azide; lead(II) nitrate; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; 5.1: Grignard reaction;