3'-azido-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine

Base Information

Chemical Name:3'-azido-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine
CAS No.:170236-41-6
Molecular Formula:C₃₅H₃₆N₈O₆
Molecular Weight:664.721
Hs Code.:

3'-azido-5'-O-(4,4'-dimethoxytrityl)-N<sub>2</sub>-isobutyryl-2',3'-dideoxyguanosine

Synonyms:3'-azido-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine

Suppliers and Price of 3'-azido-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 3'-azido-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3'-azido-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine

There total 13 articles about 3'-azido-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 719288-80-9
N²-isobutyryl-5'-(4,4'-dimethoxytrityl)-3'-mesyl-2',3'-dideoxyxyloguanosine

: 170236-41-6
3'-azido-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine

Guidance literature:: With sodium azide; In dimethyl sulfoxide; at 90 ℃;

Reference yield: 79.0%

: 719288-81-0
N²-isobutyryl-9-(3-azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)guanine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 170236-41-6
3'-azido-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine

Guidance literature:: With pyridine; for 3h;
DOI:10.1021/jo8018889

Reference yield:

: 64350-24-9
N²-isobutyryl-2'-deoxyguanosine

: 170236-41-6
3'-azido-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine

Guidance literature:: Multi-step reaction with 7 steps

1: 61 g / pyridine / 20 °C

2: 63 percent / DMAP / CH₂Cl₂ / 1 h / 20 °C

3: 86 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

4: 79 percent / pyridine / 3 h

5: L-Selectride(R) / tetrahydrofuran

6: 73 percent / pyridine

7: 16.7 g / LiN₃ / dimethylformamide / 2 h / 100 °C

With pyridine; dmap; lithium azide; tetrabutyl ammonium fluoride; L-Selectride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1081/NCN-120027826