3-allyl-8-(3-(benzyloxy)-1-methyl-1H-pyrazol-5-yl)-1H-purine-2,6(3H,7H)-dione

Base Information

Chemical Name:3-allyl-8-(3-(benzyloxy)-1-methyl-1H-pyrazol-5-yl)-1H-purine-2,6(3H,7H)-dione
CAS No.:1313388-98-5
Molecular Formula:C₁₉H₁₈N₆O₃
Molecular Weight:378.39
Hs Code.:

Synonyms:3-allyl-8-(3-(benzyloxy)-1-methyl-1H-pyrazol-5-yl)-1H-purine-2,6(3H,7H)-dione

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Chemical Property of 3-allyl-8-(3-(benzyloxy)-1-methyl-1H-pyrazol-5-yl)-1H-purine-2,6(3H,7H)-dione

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Technology Process of 3-allyl-8-(3-(benzyloxy)-1-methyl-1H-pyrazol-5-yl)-1H-purine-2,6(3H,7H)-dione

There total 2 articles about 3-allyl-8-(3-(benzyloxy)-1-methyl-1H-pyrazol-5-yl)-1H-purine-2,6(3H,7H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1313389-24-0
3-(benzyloxy)-1-methyl-1H-pyrazole-5-carboxylic acid

: 144827-93-0
C₇H₁₀N₄O₂

: 1313388-98-5
3-allyl-8-(3-(benzyloxy)-1-methyl-1H-pyrazol-5-yl)-1H-purine-2,6(3H,7H)-dione

Guidance literature:: 3-(benzyloxy)-1-methyl-1H-pyrazole-5-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

C₇H₁₀N₄O₂; In N,N-dimethyl-formamide; for 24h;

With sodium hydroxide; In water; for 1.5h;
DOI:10.1021/jm2004738

Reference yield:

: C₇H₆N₄O₄

: 1313388-98-5
3-allyl-8-(3-(benzyloxy)-1-methyl-1H-pyrazol-5-yl)-1H-purine-2,6(3H,7H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium dithionite

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 24 h

2.3: 1.5 h

With sodium dithionite; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm2004738

Reference yield:

: 1313388-98-5
3-allyl-8-(3-(benzyloxy)-1-methyl-1H-pyrazol-5-yl)-1H-purine-2,6(3H,7H)-dione

: 1313388-72-5
(R,S)-4-allyl-2-(3-(benzyloxy)-1-methyl-1H-pyrazol-5-yl)-8-ethyl-7,8-dihydro-1H-imidazo[2,1-i]purin-5(4H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; tetraphosphorus decasulfide / 5 h / 140 °C

2: sodium hydroxide / ethanol / 3 h / 20 °C

3: dimethyl sulfoxide / 1 h / 150 °C

4: thionyl chloride / dichloromethane / 18 h / 20 °C / Reflux

With pyridine; thionyl chloride; tetraphosphorus decasulfide; sodium hydroxide; In ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm2004738