N-tert-butylcarbamate-N-[1-(4-cyanomethyl-cyclohexyl)-1H-imidazo[4,5-c]quinolin-2-ylmethyl]-methanesulfonamide

Base Information

Chemical Name:N-tert-butylcarbamate-N-[1-(4-cyanomethyl-cyclohexyl)-1H-imidazo[4,5-c]quinolin-2-ylmethyl]-methanesulfonamide
CAS No.:1418003-12-9
Molecular Formula:C₂₅H₃₁N₅O₄S
Molecular Weight:497.618
Hs Code.:

Synonyms:N-tert-butylcarbamate-N-[1-(4-cyanomethyl-cyclohexyl)-1H-imidazo[4,5-c]quinolin-2-ylmethyl]-methanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-tert-butylcarbamate-N-[1-(4-cyanomethyl-cyclohexyl)-1H-imidazo[4,5-c]quinolin-2-ylmethyl]-methanesulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-tert-butylcarbamate-N-[1-(4-cyanomethyl-cyclohexyl)-1H-imidazo[4,5-c]quinolin-2-ylmethyl]-methanesulfonamide

There total 6 articles about N-tert-butylcarbamate-N-[1-(4-cyanomethyl-cyclohexyl)-1H-imidazo[4,5-c]quinolin-2-ylmethyl]-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1418002-21-7
C₁₉H₂₀N₄O

: 147751-16-4
tert-butyl (methylsulfonyl)carbamate

: 1418003-12-9
N-tert-butylcarbamate-N-[1-(4-cyanomethyl-cyclohexyl)-1H-imidazo[4,5-c]quinolin-2-ylmethyl]-methanesulfonamide

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

: 239074-29-4
trans (4-hydroxymethyl-cyclohexyl)-carbamic acid tert-butyl ester

: 1418003-12-9
N-tert-butylcarbamate-N-[1-(4-cyanomethyl-cyclohexyl)-1H-imidazo[4,5-c]quinolin-2-ylmethyl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / dichloromethane / 5 h / 0 - 20 °C

2.1: dimethyl sulfoxide / 4 h / 90 °C

3.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 20 °C / Reflux

5.1: hydrogen; palladium on activated charcoal / tetrahydrofuran; ethyl acetate / 4 h / Inert atmosphere

6.1: triethyloxonium fluoroborate / tetrahydrofuran / 3.5 h / 20 °C

6.2: 1 h / 75 °C

7.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere

With pyridine; di-isopropyl azodicarboxylate; palladium on activated charcoal; hydrogen; triethyloxonium fluoroborate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol;

Reference yield:

: 1313279-47-8
trans-(4-cyanomethyl-cyclohexyl)-carbamic acid tert-butyl ester

: 1418003-12-9
N-tert-butylcarbamate-N-[1-(4-cyanomethyl-cyclohexyl)-1H-imidazo[4,5-c]quinolin-2-ylmethyl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 20 °C / Reflux

3.1: hydrogen; palladium on activated charcoal / tetrahydrofuran; ethyl acetate / 4 h / Inert atmosphere

4.1: triethyloxonium fluoroborate / tetrahydrofuran / 3.5 h / 20 °C

4.2: 1 h / 75 °C

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; palladium on activated charcoal; hydrogen; triethyloxonium fluoroborate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; ethyl acetate; isopropyl alcohol;