7-amino-3-<3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-2'-(phenoxythiocarbonyl)-β-D-ribofuranosyl>pyrazolo<4,3-d>pyrimidine

Base Information

• Chemical Name: 7-amino-3-<3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-2'-(phenoxythiocarbonyl)-β-D-ribofuranosyl>pyrazolo<4,3-d>pyrimidine
• CAS No.: 96807-06-6
• Molecular Formula: C₂₉H₄₃N₅O₆SSi₂
• Molecular Weight: 645.927

Synonyms:7-amino-3-<3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-2'-(phenoxythiocarbonyl)-β-D-ribofuranosyl>pyrazolo<4,3-d>pyrimidine

Chemical Property of 7-amino-3-<3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-2'-(phenoxythiocarbonyl)-β-D-ribofuranosyl>pyrazolo<4,3-d>pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Technology Process of 7-amino-3-<3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-2'-(phenoxythiocarbonyl)-β-D-ribofuranosyl>pyrazolo<4,3-d>pyrimidine

There total 3 articles about 7-amino-3-<3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-2'-(phenoxythiocarbonyl)-β-D-ribofuranosyl>pyrazolo<4,3-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.7%

7-amino-3-<3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-β-D-ribofuranosyl>pyrazolo<4,3-d>pyrimidine (87791-95-5) + phenylcarbonochloridothioate (1005-56-7) → 7-amino-3-<3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-2'-(phenoxythiocarbonyl)-β-D-ribofuranosyl>pyrazolo<4,3-d>pyrimidine (96807-06-6)

Guidance literature:

With dmap; In acetonitrile; for 8h; Ambient temperature;

DOI:10.1080/15257779408013229

Reference yield:

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (69304-37-6) → 7-amino-3-<3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-2'-(phenoxythiocarbonyl)-β-D-ribofuranosyl>pyrazolo<4,3-d>pyrimidine (96807-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 2.5 h / 20 °C

2: DMAP / acetonitrile / 6.5 h / 20 °C

With pyridine; dmap; In acetonitrile;

DOI:10.1021/jo00127a010

Reference yield:

formycin (57101-52-7) → 7-amino-3-<3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-2'-(phenoxythiocarbonyl)-β-D-ribofuranosyl>pyrazolo<4,3-d>pyrimidine (96807-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 2.5 h / 20 °C

2: DMAP / acetonitrile / 6.5 h / 20 °C

With pyridine; dmap; In acetonitrile;

DOI:10.1021/jo00127a010

upstream raw materials:

7-amino-3-<3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-β-D-ribofuranosyl>pyrazolo<4,3-d>pyrimidine

phenylcarbonochloridothioate

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

formycin

Downstream raw materials:

N'-(3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-N,N-dimethyl-formamidine

2'-Deoxyformycin A

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