CH₂OC₁₄H₁₉ON

Base Information

• Chemical Name: CH₂OC₁₄H₁₉ON
• CAS No.: 950818-63-0
• Molecular Formula: C₁₅H₂₁NO₂
• Molecular Weight: 247.337
• Mol file: 950818-63-0.mol

Synonyms:CH₂OC₁₄H₁₉ON

Chemical Property of CH₂OC₁₄H₁₉ON

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of CH₂OC₁₄H₁₉ON

There total 3 articles about CH₂OC₁₄H₁₉ON which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-amino-3-methoxyphenyl)ethanone (42465-54-3) + hex-1-yne (693-02-7) → CH2OC14H19ON (950818-63-0)

Guidance literature:

hex-1-yne; With ethylmagnesium bromide; In tetrahydrofuran; at 50 ℃; for 2h;

1-(2-amino-3-methoxyphenyl)ethanone; In tetrahydrofuran; at 50 ℃; Further stages.;

DOI:10.1021/jo071094z

Reference yield:

1-(3-methoxy-2-nitrophenyl)ethanone (33852-43-6) → CH2OC14H19ON (950818-63-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 75 percent / Sn; aq. HCl / H₂O / 4 h / Heating

2.1: EtMgBr / tetrahydrofuran / 2 h / 50 °C

2.2: tetrahydrofuran / 50 °C

With hydrogenchloride; tin; ethylmagnesium bromide; In tetrahydrofuran; water;

DOI:10.1021/jo071094z

Reference yield:

1-(3-Methoxyphenyl)ethanone (586-37-8) → CH2OC14H19ON (950818-63-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 30 percent / HNO₃ / 54 h / 20 °C

2.1: 75 percent / Sn; aq. HCl / H₂O / 4 h / Heating

3.1: EtMgBr / tetrahydrofuran / 2 h / 50 °C

3.2: tetrahydrofuran / 50 °C

With hydrogenchloride; tin; ethylmagnesium bromide; nitric acid; In tetrahydrofuran; water;

DOI:10.1021/jo071094z

upstream raw materials:

1-(2-amino-3-methoxyphenyl)ethanone

hex-1-yne

1-(3-methoxy-2-nitrophenyl)ethanone

1-(3-Methoxyphenyl)ethanone

Downstream raw materials:

2-methoxy-6-(1-methylenehept-2-ynyl)aniline

Refernces

• 1、 Gabriele, Bartolo,Mancuso, Raffaella,Salerno, Giuseppe,Lupinacci, Elvira,Ruffolo, Giuseppe,Costa, Mirco. "Versatile synthesis of quinoline-3-carboxylic esters and indol-2-acetic esters by palladium-catalyzed carbonylation of 1-(2-aminoaryl)-2-Yn-1-Ols". . p. 4971 - 4977. Retrieved 2008/12/20.