8-fluoro-5-(4-fluorophenyl)-1-(4-methylpiperazinoacetyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Base Information

• Chemical Name: 8-fluoro-5-(4-fluorophenyl)-1-(4-methylpiperazinoacetyl)-2,3,4,5-tetrahydro-1H-1-benzazepine
• CAS No.: 77796-01-1
• Molecular Formula: C₂₃H₂₇F₂N₃O
• Molecular Weight: 399.484

Synonyms:8-fluoro-5-(4-fluorophenyl)-1-(4-methylpiperazinoacetyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Chemical Property of 8-fluoro-5-(4-fluorophenyl)-1-(4-methylpiperazinoacetyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Chemical Property:

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Technology Process of 8-fluoro-5-(4-fluorophenyl)-1-(4-methylpiperazinoacetyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

There total 2 articles about 8-fluoro-5-(4-fluorophenyl)-1-(4-methylpiperazinoacetyl)-2,3,4,5-tetrahydro-1H-1-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-methyl-piperazine (109-01-3) + 1-(chloroacetyl)-8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepine (77795-92-7) → 8-fluoro-5-(4-fluorophenyl)-1-(4-methylpiperazinoacetyl)-2,3,4,5-tetrahydro-1H-1-benzazepine (77796-01-1)

Guidance literature:

In benzene; for 9h; Heating;

DOI:10.1135/cccc19810148

Reference yield:

8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepine (68351-39-3) → 8-fluoro-5-(4-fluorophenyl)-1-(4-methylpiperazinoacetyl)-2,3,4,5-tetrahydro-1H-1-benzazepine (77796-01-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / K₂CO₃ / CHCl₃ / 1 h / Heating

2: 92 percent / benzene / 9 h / Heating

With potassium carbonate; In chloroform; benzene;

DOI:10.1135/cccc19810148

Reference yield: 98.0%

8-fluoro-5-(4-fluorophenyl)-1-(4-methylpiperazinoacetyl)-2,3,4,5-tetrahydro-1H-1-benzazepine (77796-01-1) → 8-Fluoro-5-(4-fluoro-phenyl)-1-[2-(4-methyl-piperazin-1-yl)-ethyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepine (90069-20-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; benzene; for 7h; Heating;

DOI:10.1135/cccc19810148

upstream raw materials:

1-methyl-piperazine

1-(chloroacetyl)-8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Downstream raw materials:

8-Fluoro-5-(4-fluoro-phenyl)-1-[2-(4-methyl-piperazin-1-yl)-ethyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepine

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