2-benzyloxymethyl-5-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-3,4-dihydro-2H-pyrrole

Base Information

Chemical Name:2-benzyloxymethyl-5-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-3,4-dihydro-2H-pyrrole
CAS No.:748781-28-4
Molecular Formula:C₃₂H₄₁NO₂Si
Molecular Weight:499.769
Hs Code.:

2-benzyloxymethyl-5-[4-(<i>tert</i>-butyl-diphenyl-silanyloxy)-butyl]-3,4-dihydro-2<i>H</i>-pyrrole

Synonyms:2-benzyloxymethyl-5-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-3,4-dihydro-2H-pyrrole

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Chemical Property of 2-benzyloxymethyl-5-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-3,4-dihydro-2H-pyrrole

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Technology Process of 2-benzyloxymethyl-5-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-3,4-dihydro-2H-pyrrole

There total 3 articles about 2-benzyloxymethyl-5-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-3,4-dihydro-2H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 748781-27-3
4-(5-benzyloxymethyl-4,5-dihydro-3H-pyrrol-2-yl)-butan-1-ol

: 748781-28-4
2-benzyloxymethyl-5-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-3,4-dihydro-2H-pyrrole

Guidance literature:: With dmap; TEA; In dichloromethane;
DOI:10.1016/j.tetlet.2004.05.142

Reference yield:

: 152500-21-5
(S)-5-benzyloxymetyl-1-tert-butoxycarbonyl-2-pyrrolidinone

: 748781-28-4
2-benzyloxymethyl-5-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-3,4-dihydro-2H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 85 percent / tetrahydrofuran / 0 °C

2.1: TFA / CH₂Cl₂ / 0 - 20 °C

2.2: 87 percent / NaOH / 0 °C

3.1: 79 percent / DMAP; TEA / CH₂Cl₂

With dmap; TEA; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1.1: Grignard reaction;
DOI:10.1016/j.tetlet.2004.05.142

Reference yield:

: 748781-26-2
[1-benzyloxymethyl-8-(4-methoxy-benzyloxy)-4-oxo-octyl]-carbamic acid tert-butyl ester

: 748781-28-4
2-benzyloxymethyl-5-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-3,4-dihydro-2H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1.1: TFA / CH₂Cl₂ / 0 - 20 °C

1.2: 87 percent / NaOH / 0 °C

2.1: 79 percent / DMAP; TEA / CH₂Cl₂

With dmap; TEA; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.tetlet.2004.05.142