(5R)-<(2R)-benzyloxypropyl>-2-tetrahydrofuran

Base Information

Chemical Name:(5R)-<(2R)-benzyloxypropyl>-2-tetrahydrofuran
CAS No.:139932-06-2
Molecular Formula:C₁₉H₂₄O₆
Molecular Weight:348.396
Hs Code.:

(5R)-<(2R)-benzyloxypropyl>-2-<di(methoxycarbonyl)methylene>tetrahydrofuran

Synonyms:(5R)-<(2R)-benzyloxypropyl>-2-tetrahydrofuran

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Chemical Property of (5R)-<(2R)-benzyloxypropyl>-2-tetrahydrofuran

Chemical Property:

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Technology Process of (5R)-<(2R)-benzyloxypropyl>-2-tetrahydrofuran

There total 8 articles about (5R)-<(2R)-benzyloxypropyl>-2-tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 6773-29-1
dimethyl diazomalonate

: 139932-05-1
(5R)-<(2R)-benzyloxypropyl>tetrahydro-2-furanthione

: 139932-06-2
(5R)-<(2R)-benzyloxypropyl>-2-tetrahydrofuran

Guidance literature:: With rhodium(II) acetate; In toluene; for 3h; Heating;
DOI:10.1016/S0040-4020(01)80580-9

Reference yield:

: 89104-05-2
(4R,6R)-6-Benzyloxy-hept-1-en-4-ol

: 139932-06-2
(5R)-<(2R)-benzyloxypropyl>-2-tetrahydrofuran

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 18 h / Ambient temperature

2: 1) BH₃, 2) 30percent H₂O₂, 3 M NaOH / 1) THF, r.t., 1 h, 2) r.t., 1 h

3: 90 percent / (COCl)2, DMSO / CH₂Cl₂ / 0.83 h / -50 °C

4: 90 percent / 2-methyl-2-butene, NaCl, KH₂PO₄, H₂O / 2-methyl-propan-2-ol / 3 h / Ambient temperature

5: 100 percent / 10percent HCl / tetrahydrofuran / 3 h / Ambient temperature

6: 83 percent / toluene / 0.5 h / Heating; Lawesson's reagent

7: 98 percent / rhodium acetate / toluene / 3 h / Heating

With rhodium(II) acetate; hydrogenchloride; sodium hydroxide; potassium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; borane; water; dihydrogen peroxide; pyridinium p-toluenesulfonate; dimethyl sulfoxide; sodium chloride; In tetrahydrofuran; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)80580-9

Reference yield:

: 86040-07-5
(R)-3-benzyloxybutanal

: 139932-06-2
(5R)-<(2R)-benzyloxypropyl>-2-tetrahydrofuran

Guidance literature:: Multi-step reaction with 8 steps

1: TiCl₄ / CH₂Cl₂ / -78 °C

2: 98 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 18 h / Ambient temperature

3: 1) BH₃, 2) 30percent H₂O₂, 3 M NaOH / 1) THF, r.t., 1 h, 2) r.t., 1 h

4: 90 percent / (COCl)2, DMSO / CH₂Cl₂ / 0.83 h / -50 °C

5: 90 percent / 2-methyl-2-butene, NaCl, KH₂PO₄, H₂O / 2-methyl-propan-2-ol / 3 h / Ambient temperature

6: 100 percent / 10percent HCl / tetrahydrofuran / 3 h / Ambient temperature

7: 83 percent / toluene / 0.5 h / Heating; Lawesson's reagent

8: 98 percent / rhodium acetate / toluene / 3 h / Heating

With rhodium(II) acetate; hydrogenchloride; sodium hydroxide; potassium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; borane; water; dihydrogen peroxide; pyridinium p-toluenesulfonate; titanium tetrachloride; dimethyl sulfoxide; sodium chloride; In tetrahydrofuran; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)80580-9