3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-3-((3-(hydroxymethyl)phenyl)sulfonyl)thiazolidine-2-carbonyl)oxy)ethyl)pyridine-1-oxide

Base Information

• Chemical Name: 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-3-((3-(hydroxymethyl)phenyl)sulfonyl)thiazolidine-2-carbonyl)oxy)ethyl)pyridine-1-oxide
• CAS No.: 1416000-56-0
• Molecular Formula: C₂₉H₂₈Cl₂F₂N₂O₈S₂
• Molecular Weight: 705.585
• Mol file: 1416000-56-0.mol

Synonyms:3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-3-((3-(hydroxymethyl)phenyl)sulfonyl)thiazolidine-2-carbonyl)oxy)ethyl)pyridine-1-oxide

Chemical Property of 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-3-((3-(hydroxymethyl)phenyl)sulfonyl)thiazolidine-2-carbonyl)oxy)ethyl)pyridine-1-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-3-((3-(hydroxymethyl)phenyl)sulfonyl)thiazolidine-2-carbonyl)oxy)ethyl)pyridine-1-oxide

There total 2 articles about 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-3-((3-(hydroxymethyl)phenyl)sulfonyl)thiazolidine-2-carbonyl)oxy)ethyl)pyridine-1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.3%

3-(hydroxymethyl)benzenesulfonylchloride (1196475-44-1) + [(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl](2S)-thiazolidine-2-carboxylate hydrochloride (1415994-84-1) → 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-3-((3-(hydroxymethyl)phenyl)sulfonyl)thiazolidine-2-carbonyl)oxy)ethyl)pyridine-1-oxide (1416000-56-0)

Guidance literature:

With pyridine; In dichloromethane; acetonitrile; at 0 - 20 ℃;

Reference yield:

3-Carboxybenzenesulfonyl chloride (4025-64-3) → 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-3-((3-(hydroxymethyl)phenyl)sulfonyl)thiazolidine-2-carbonyl)oxy)ethyl)pyridine-1-oxide (1416000-56-0)

Guidance literature:

Multi-step reaction with 2 steps

1: borane-THF / tetrahydrofuran / 0 - 20 °C

2: pyridine / dichloromethane; acetonitrile / 0 - 20 °C

With pyridine; borane-THF; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield: 18.7%

3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-3-((3-(hydroxymethyl)phenyl)sulfonyl)thiazolidine-2-carbonyl)oxy)ethyl)pyridine-1-oxide (1416000-56-0) + (R)-3-(((2-fluorophenyl)((quinuclidin-3-yloxy)carbonyl)amino)-methyl)benzoic acid (1612232-95-7) → 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-3-((3-(((3-(((2-fluorophenyl)(((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)benzoyl)oxy)methyl)phenyl)sulfonyl)thiazolidine-2-carbonyl)oxy)ethyl)pyridine-1-oxide formate

Guidance literature:

3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-3-((3-(hydroxymethyl)phenyl)sulfonyl)thiazolidine-2-carbonyl)oxy)ethyl)pyridine-1-oxide; (R)-3-(((2-fluorophenyl)((quinuclidin-3-yloxy)carbonyl)amino)-methyl)benzoic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

With formic acid; ammonium bicarbonate;

upstream raw materials:

3-Carboxybenzenesulfonyl chloride

3-(hydroxymethyl)benzenesulfonylchloride

[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl](2S)-thiazolidine-2-carboxylate hydrochloride