4-methyl-5-[4-naphthalen-2-yl-5-(4-trifluoromethyl-benzylsulfanyl)-4H-[1,2,4]triazol-3-yl]-[1,2,3]thiadiazole

Base Information

• Chemical Name: 4-methyl-5-[4-naphthalen-2-yl-5-(4-trifluoromethyl-benzylsulfanyl)-4H-[1,2,4]triazol-3-yl]-[1,2,3]thiadiazole
• CAS No.: 318467-54-8
• Molecular Formula: C₂₃H₁₆F₃N₅S₂
• Molecular Weight: 483.541

Synonyms:4-methyl-5-[4-naphthalen-2-yl-5-(4-trifluoromethyl-benzylsulfanyl)-4H-[1,2,4]triazol-3-yl]-[1,2,3]thiadiazole

Chemical Property of 4-methyl-5-[4-naphthalen-2-yl-5-(4-trifluoromethyl-benzylsulfanyl)-4H-[1,2,4]triazol-3-yl]-[1,2,3]thiadiazole

Chemical Property:

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Technology Process of 4-methyl-5-[4-naphthalen-2-yl-5-(4-trifluoromethyl-benzylsulfanyl)-4H-[1,2,4]triazol-3-yl]-[1,2,3]thiadiazole

There total 2 articles about 4-methyl-5-[4-naphthalen-2-yl-5-(4-trifluoromethyl-benzylsulfanyl)-4H-[1,2,4]triazol-3-yl]-[1,2,3]thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-naphthyl isothiocyanate (1636-33-5) → 4-methyl-5-[4-naphthalen-2-yl-5-(4-trifluoromethyl-benzylsulfanyl)-4H-[1,2,4]triazol-3-yl]-[1,2,3]thiadiazole (318467-54-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 79 percent / aq. NaOH / ethanol / 3 h

2.1: 73 percent / NaHCO₃ / H₂O; dimethylformamide / 5 h / 140 °C

3.1: KOH / ethanol / 0.5 h

3.2: 90 percent / ethanol / 1.5 h / 20 °C

With potassium hydroxide; sodium hydroxide; sodium hydrogencarbonate; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1002/1521-4184(200010)333:10<347::AID-ARDP347>3.0.CO;2-6

Reference yield:

C15H13N5OS2 (318467-31-1) → 4-methyl-5-[4-naphthalen-2-yl-5-(4-trifluoromethyl-benzylsulfanyl)-4H-[1,2,4]triazol-3-yl]-[1,2,3]thiadiazole (318467-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 73 percent / NaHCO₃ / H₂O; dimethylformamide / 5 h / 140 °C

2.1: KOH / ethanol / 0.5 h

2.2: 90 percent / ethanol / 1.5 h / 20 °C

With potassium hydroxide; sodium hydrogencarbonate; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1002/1521-4184(200010)333:10<347::AID-ARDP347>3.0.CO;2-6

Reference yield: 44.0%

4-methyl-5-[4-naphthalen-2-yl-5-(4-trifluoromethyl-benzylsulfanyl)-4H-[1,2,4]triazol-3-yl]-[1,2,3]thiadiazole (318467-54-8) → 4-methyl-5-[4-naphthalen-2-yl-5-(4-trifluoromethyl-phenylmethanesulfonyl)-4H-[1,2,4]triazol-3-yl]-[1,2,3]thiadiazole

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 0.5h;

DOI:10.1002/1521-4184(200010)333:10<347::AID-ARDP347>3.0.CO;2-6

upstream raw materials:

2-naphthyl isothiocyanate

C₁₅H₁₃N₅OS₂

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