(R)-1-(3-Hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride

Base Information

Chemical Name:(R)-1-(3-Hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride
CAS No.:6507-35-3
Molecular Formula:C₁₈H₂₁NO₄*ClH
Molecular Weight:351.83
Hs Code.:

Synonyms:(R)-1-(3-Hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride

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Chemical Property of (R)-1-(3-Hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride

Chemical Property:

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Technology Process of (R)-1-(3-Hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride

There total 5 articles about (R)-1-(3-Hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72258-91-4
1,2-dehydronorreticuline

: 6507-35-3
(R)-1-(3-Hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; ammonium hydroxide; Yield given;
DOI:10.1021/jo01292a008

Reference yield:

: 1131-94-8
homoisovanillic acid

: 6507-35-3
(R)-1-(3-Hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 90.4 percent / Heating

2: POCl₃ / acetonitrile / Heating

3: NaBH₄ / aq. NH₃; tetrahydrofuran

With sodium tetrahydroborate; trichlorophosphate; In tetrahydrofuran; ammonium hydroxide; acetonitrile;
DOI:10.1021/jo01292a008

Reference yield:

: 4468-59-1
4-hydroxy-3-methoxyphenylacetonitrile

: 6507-35-3
(R)-1-(3-Hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) BH₃, HCl; 2.) aqueous NH₃

2: 90.4 percent / Heating

3: POCl₃ / acetonitrile / Heating

4: NaBH₄ / aq. NH₃; tetrahydrofuran

With hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; borane; trichlorophosphate; In tetrahydrofuran; ammonium hydroxide; acetonitrile;
DOI:10.1021/jo01292a008