1,5-anhydro-2,3-dideoxy-6-O-monomethoxytrityl-2-(thymin-1-yl)-D-lyxohexitol

Base Information

• Chemical Name: 1,5-anhydro-2,3-dideoxy-6-O-monomethoxytrityl-2-(thymin-1-yl)-D-lyxohexitol
• CAS No.: 175670-95-8
• Molecular Formula: C₃₁H₃₂N₂O₆
• Molecular Weight: 528.605

Synonyms:1,5-anhydro-2,3-dideoxy-6-O-monomethoxytrityl-2-(thymin-1-yl)-D-lyxohexitol

Chemical Property of 1,5-anhydro-2,3-dideoxy-6-O-monomethoxytrityl-2-(thymin-1-yl)-D-lyxohexitol

Chemical Property:

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Technology Process of 1,5-anhydro-2,3-dideoxy-6-O-monomethoxytrityl-2-(thymin-1-yl)-D-lyxohexitol

There total 1 articles about 1,5-anhydro-2,3-dideoxy-6-O-monomethoxytrityl-2-(thymin-1-yl)-D-lyxohexitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

1-{(3S,6R)-6-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-5-oxo-tetrahydro-pyran-3-yl}-5-methyl-1H-pyrimidine-2,4-dione (175471-44-0) → 1,5-anhydro-2,3-dideoxy-6-O-monomethoxytrityl-2-(thymin-1-yl)-D-lyxohexitol (175670-95-8)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 2.5h;

DOI:10.1080/07328319608002387

Reference yield:

1,5-anhydro-2,3-dideoxy-6-O-monomethoxytrityl-2-(thymin-1-yl)-D-lyxohexitol (175670-95-8) → 1,5-anhydro-2,3,4-trideoxy-6-O-monomethoxytrityl-2-(thymin-1-yl)-D-threohex-enose

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 2.5 h / Ambient temperature

2: LiN₃ / dimethylformamide / 16 h / 80 °C

With lithium azide; In pyridine; N,N-dimethyl-formamide;

DOI:10.1080/07328319608002387

Reference yield:

1,5-anhydro-2,3-dideoxy-6-O-monomethoxytrityl-2-(thymin-1-yl)-D-lyxohexitol (175670-95-8) → 1,5-anhydro-4-azido-2,3,4-trideoxy-6-O-monomethoxytrityl-2-(thymin-1-yl)-D-arabinohexitol

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 2.5 h / Ambient temperature

2: LiN₃ / dimethylformamide / 16 h / 80 °C

With lithium azide; In pyridine; N,N-dimethyl-formamide;

DOI:10.1080/07328319608002387

upstream raw materials:

1-{(3S,6R)-6-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-5-oxo-tetrahydro-pyran-3-yl}-5-methyl-1H-pyrimidine-2,4-dione

Downstream raw materials:

Methanesulfonic acid (2R,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-pyran-3-yl ester

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