(S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)sulfamide

Base Information

Chemical Name:(S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)sulfamide
CAS No.:1413605-69-2
Molecular Formula:C₂₁H₂₁N₅O₃S₂
Molecular Weight:455.561
Hs Code.:

Synonyms:(S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)sulfamide

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Chemical Property of (S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)sulfamide

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Technology Process of (S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)sulfamide

There total 7 articles about (S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)sulfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1413605-57-8
(S)-5-(3-(1-amino-2,3-dihydro-1H-inden-4-yl)-1,2,4-thiadiazol-5-yl)-2-isopropoxybenzonitrile hydrochloride

: 1413605-69-2
(S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)sulfamide

Guidance literature:: With SULFAMIDE; In 1,4-dioxane; at 90 ℃; for 16h;

Reference yield:

: 1307231-21-5
(S)-tert-butyl 4-bromo-2,3-dihydro-1H-inden-1-ylcarbamate

: 1413605-69-2
(S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)sulfamide

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 8 h / 85 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate tribasic trihydrate / water; N,N-dimethyl-formamide / 5 h / 100 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane / 3.5 h / 55 °C

4: SULFAMIDE / 1,4-dioxane / 16 h / 90 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate tribasic trihydrate; potassium acetate; SULFAMIDE; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1307231-22-6
(S)-tert-butyl (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-yl)carbamate

: 1413605-69-2
(S)-N-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)sulfamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate tribasic trihydrate / water; N,N-dimethyl-formamide / 5 h / 100 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 3.5 h / 55 °C

3: SULFAMIDE / 1,4-dioxane / 16 h / 90 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate tribasic trihydrate; SULFAMIDE; In 1,4-dioxane; water; N,N-dimethyl-formamide;