ethyl 4-(3-bromophenyl)-2-(tert-butoxycarbonylamino)-4-methyl-5,6-dihydro-4H-1,3-thiazine-6-carboxylate

Base Information

Chemical Name:ethyl 4-(3-bromophenyl)-2-(tert-butoxycarbonylamino)-4-methyl-5,6-dihydro-4H-1,3-thiazine-6-carboxylate
CAS No.:1194045-12-9
Molecular Formula:C₁₉H₂₅BrN₂O₄S
Molecular Weight:457.388
Hs Code.:

Synonyms:ethyl 4-(3-bromophenyl)-2-(tert-butoxycarbonylamino)-4-methyl-5,6-dihydro-4H-1,3-thiazine-6-carboxylate

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Chemical Property of ethyl 4-(3-bromophenyl)-2-(tert-butoxycarbonylamino)-4-methyl-5,6-dihydro-4H-1,3-thiazine-6-carboxylate

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Technology Process of ethyl 4-(3-bromophenyl)-2-(tert-butoxycarbonylamino)-4-methyl-5,6-dihydro-4H-1,3-thiazine-6-carboxylate

There total 1 articles about ethyl 4-(3-bromophenyl)-2-(tert-butoxycarbonylamino)-4-methyl-5,6-dihydro-4H-1,3-thiazine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1194045-10-7
ethyl 2-amino-4-(3-bromophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazine-6-carboxylate

: 1194045-12-9
ethyl 4-(3-bromophenyl)-2-(tert-butoxycarbonylamino)-4-methyl-5,6-dihydro-4H-1,3-thiazine-6-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; water; for 60h; Saturated solution;

Reference yield: 29.0%

: 1194045-12-9
ethyl 4-(3-bromophenyl)-2-(tert-butoxycarbonylamino)-4-methyl-5,6-dihydro-4H-1,3-thiazine-6-carboxylate

: (+/-) tert-butyl (4S,6S)-4-(3-bromophenyl)-6-(hydroxymethyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-ylcarbamate

Guidance literature:: ethyl 4-(3-bromophenyl)-2-(tert-butoxycarbonylamino)-4-methyl-5,6-dihydro-4H-1,3-thiazine-6-carboxylate; With lithium borohydride; In tetrahydrofuran; ethanol; at 0 - 20 ℃;

With ammonium chloride; In tetrahydrofuran; ethanol; Saturated solution;

Reference yield: 14.0%

: 1194045-12-9
ethyl 4-(3-bromophenyl)-2-(tert-butoxycarbonylamino)-4-methyl-5,6-dihydro-4H-1,3-thiazine-6-carboxylate

: (4S,6R)-ethyl 4-(3-bromophenyl)-2-(tert-butoxycarbonylamino)-4-methyl-5,6-dihydro-4H-1,3-thiazine-6-carboxylate

: 1194045-14-1
(4S,6S)-ethyl 4-(3-bromophenyl)-2-(tert-butoxycarbonylamino)-4-methyl-5,6-dihydro-4H-1,3-thiazine-6-carboxylate

: (4R,6R)-ethyl 4-(3-bromophenyl)-2-(tert-butoxycarbonylamino)-4-methyl-5,6-dihydro-4H-1,3-thiazine-6-carboxylate

: (4R,6S)-ethyl 4-(3-bromophenyl)-2-(tert-butoxycarbonylamino)-4-methyl-5,6-dihydro-4H-1,3-thiazine-6-carboxylate

Guidance literature:: ethyl 4-(3-bromophenyl)-2-(tert-butoxycarbonylamino)-4-methyl-5,6-dihydro-4H-1,3-thiazine-6-carboxylate; With Chiralcel OJ 8×32 cm; In ethanol; n-heptane; Resolution of racemate;

With Chiralcel OJ 8×32 cm; In n-heptane; isopropyl alcohol;