N₁-((1S,3R)-3-N-Boc-aminocyclopentylmethyl)-3,4-di(difluoromethoxy)-benzamide

Base Information

Chemical Name:N₁-((1S,3R)-3-N-Boc-aminocyclopentylmethyl)-3,4-di(difluoromethoxy)-benzamide
CAS No.:874987-28-7
Molecular Formula:C₂₀H₂₆F₄N₂O₅
Molecular Weight:450.43
Hs Code.:

N<sub>1</sub>-((1S,3R)-3-N-Boc-aminocyclopentylmethyl)-3,4-di(difluoromethoxy)-benzamide

Synonyms:N₁-((1S,3R)-3-N-Boc-aminocyclopentylmethyl)-3,4-di(difluoromethoxy)-benzamide

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Chemical Property of N₁-((1S,3R)-3-N-Boc-aminocyclopentylmethyl)-3,4-di(difluoromethoxy)-benzamide

Chemical Property:

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Technology Process of N₁-((1S,3R)-3-N-Boc-aminocyclopentylmethyl)-3,4-di(difluoromethoxy)-benzamide

There total 3 articles about N₁-((1S,3R)-3-N-Boc-aminocyclopentylmethyl)-3,4-di(difluoromethoxy)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 162401-60-7
3,4-Bis(difluoromethoxy) benzoic acid

: 347185-71-1,862700-28-5,862700-45-6
(1S,3R)-(+)-3-N-boc-aminocyclopentylmethylamine

: 874987-28-7
N₁-((1S,3R)-3-N-Boc-aminocyclopentylmethyl)-3,4-di(difluoromethoxy)-benzamide

Guidance literature:: 3,4-Bis(difluoromethoxy) benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h;

(1S,3R)-(+)-3-N-boc-aminocyclopentylmethylamine; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h;

Reference yield:

: 347185-70-0
(1S,3R)-(+)-3-N-boc-aminocyclopentylmethyl azide

: 874987-28-7
N₁-((1S,3R)-3-N-Boc-aminocyclopentylmethyl)-3,4-di(difluoromethoxy)-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / 5%-palladium/activated carbon / methanol / 2585.81 Torr

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C

2.2: 12 h / 0 - 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 5%-palladium/activated carbon; In methanol; dichloromethane;

Reference yield:

: 862700-29-6
(1S,3R)-(3-((tert-butoxycarbonyl)amino)cyclopentyl)methylmethanesulfonate

: 874987-28-7
N₁-((1S,3R)-3-N-Boc-aminocyclopentylmethyl)-3,4-di(difluoromethoxy)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide / N,N-dimethyl-formamide / 6 h / 60 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 2585.81 Torr

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C

3.2: 12 h / 0 - 20 °C

With sodium azide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 5%-palladium/activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;