acetic acid 6-tert-butoxycarbonylamino-1-(2,4-dimethoxy-benzyl)-7-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl ester

Base Information

Chemical Name:acetic acid 6-tert-butoxycarbonylamino-1-(2,4-dimethoxy-benzyl)-7-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl ester
CAS No.:885503-03-7
Molecular Formula:C₂₂H₃₀N₂O₇
Molecular Weight:434.489
Hs Code.:

acetic acid 6-<i>tert</i>-butoxycarbonylamino-1-(2,4-dimethoxy-benzyl)-7-oxo-2,3,4,7-tetrahydro-1<i>H</i>-azepin-3-yl ester

Synonyms:acetic acid 6-tert-butoxycarbonylamino-1-(2,4-dimethoxy-benzyl)-7-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl ester

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Chemical Property of acetic acid 6-tert-butoxycarbonylamino-1-(2,4-dimethoxy-benzyl)-7-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl ester

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Technology Process of acetic acid 6-tert-butoxycarbonylamino-1-(2,4-dimethoxy-benzyl)-7-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl ester

There total 3 articles about acetic acid 6-tert-butoxycarbonylamino-1-(2,4-dimethoxy-benzyl)-7-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: acetic acid 1-{[(2-tert-butoxycarbonylamino-but-2-enoyl)-(2,4-dimethoxy-benzyl)-amino]-methyl}-but-3-enyl ester

: 885503-03-7
acetic acid 6-tert-butoxycarbonylamino-1-(2,4-dimethoxy-benzyl)-7-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl ester

Guidance literature:: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.tetlet.2006.03.022

Reference yield:

: 885503-10-6
1-(2,4-dimethoxy-benzylamino)-pent-4-en-2-ol

: 885503-03-7
acetic acid 6-tert-butoxycarbonylamino-1-(2,4-dimethoxy-benzyl)-7-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / EDC*HCl; HOBT; DMAP / 20 °C

2: 95 percent / pyridine / 20 °C

3: 95 percent / Grubb's catalyst 2nd generation / CH₂Cl₂ / 20 °C

With pyridine; dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane;
DOI:10.1016/j.tetlet.2006.03.022

Reference yield:

: {1-[(2,4-dimethoxy-benzyl)-(2-hydroxy-pent-4-enyl)-carbamoyl]-propenyl}-carbamic acid tert-butyl ester

: 885503-03-7
acetic acid 6-tert-butoxycarbonylamino-1-(2,4-dimethoxy-benzyl)-7-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / pyridine / 20 °C

2: 95 percent / Grubb's catalyst 2nd generation / CH₂Cl₂ / 20 °C

With pyridine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane;
DOI:10.1016/j.tetlet.2006.03.022