C₂₁H₁₈ClNO₅S

Base Information

• Chemical Name: C₂₁H₁₈ClNO₅S
• CAS No.: 1374779-39-1
• Molecular Formula: C₂₁H₁₈ClNO₅S
• Molecular Weight: 431.897

Synonyms:C₂₁H₁₈ClNO₅S

Chemical Property of C₂₁H₁₈ClNO₅S

Chemical Property:

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Technology Process of C₂₁H₁₈ClNO₅S

There total 6 articles about C₂₁H₁₈ClNO₅S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitroisophthalic acid (4315-09-7) → C21H18ClNO5S (1374779-39-1)

Guidance literature:

Multi-step reaction with 5 steps

1: sulfuric acid / methanol / 4 h / Reflux

2: sulfuric acid / 1,4-dioxane / 48 h / -15 °C

3: water; lithium hydroxide / tetrahydrofuran

4: hydrogen / palladium 10% on activated carbon / methanol / 20 h

5: tetrahydrofuran / 14 h / Reflux

With sulfuric acid; water; hydrogen; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol;

Reference yield:

t-butyl 2-amino-5-carboxybenzoate (905302-96-7) + 6-Chlorbenzothiophen-2-carbonylchlorid (105191-51-3) → C21H18ClNO5S (1374779-39-1)

Guidance literature:

In tetrahydrofuran; for 14h; Reflux;

Reference yield:

2,4-dimethylnitrobenzene (89-87-2,156617-89-9,37551-97-6) → C21H18ClNO5S (1374779-39-1)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium permanganate / water / 90 °C

2: sulfuric acid / methanol / 4 h / Reflux

3: sulfuric acid / 1,4-dioxane / 48 h / -15 °C

4: water; lithium hydroxide / tetrahydrofuran

5: hydrogen / palladium 10% on activated carbon / methanol / 20 h

6: tetrahydrofuran / 14 h / Reflux

With potassium permanganate; sulfuric acid; water; hydrogen; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water;

upstream raw materials:

2,4-dimethylnitrobenzene

4-nitroisophthalic acid

5-(methoxycarbonyl)-2-nitrobenzoic acid

t-butyl 5-methoxycarbonyl-2-nitrobenzoate

Downstream raw materials:

C₃₂H₃₁ClN₂O₅S

2-(6-chlorobenzo[b]thiophene-2-carboxamido)-5-(4-phenoxypiperidine-1-carbonyl)benzoic acid

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