Technology Process of 1-[3,5-di(benzyloxy)-(2S,3R,3aS,6aR)-perhydrofuro[3,2-b]furan-2-yl-methyl]-5-methyl-1,2,3,4-tetrahydro-2,4-pyrimidinedione
There total 8 articles about 1-[3,5-di(benzyloxy)-(2S,3R,3aS,6aR)-perhydrofuro[3,2-b]furan-2-yl-methyl]-5-methyl-1,2,3,4-tetrahydro-2,4-pyrimidinedione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
thymin;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 90 ℃;
for 0.25h;
3,5-di(benzyloxy)-2-(4-methylphenylsulfonyloxymethyl)-(2S,3R,3aS,6aR)-perhydrofuro[3,2-b]furan;
In
N,N-dimethyl-formamide; mineral oil;
at 90 ℃;
for 3h;
DOI:10.1016/j.carres.2012.01.018
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sulfuric acid; water / 1,4-dioxane / 2 h / 80 °C
2.1: oxygen; copper(l) chloride; palladium dichloride / water; N,N-dimethyl-formamide / 4 h / 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / Cooling
3.2: 1 h / 0 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 90 °C
4.2: 3 h / 90 °C
With
sulfuric acid; water; oxygen; sodium hydride; copper(l) chloride; palladium dichloride;
In
1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.carres.2012.01.018
-
-
7757-38-2,14131-84-1,23262-78-4,27108-13-0,33823-04-0,34685-42-2,57819-52-0,78039-08-4,78039-12-0,78964-16-6,94842-76-9,149342-31-4
2,3,5,6-di-O-isopropylidene-D-mannofuranose
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 10 °C
1.2: 10 - 20 °C
2.1: pyridine; dmap / 3.5 h / 0 - 20 °C
3.1: bismuth(III) chloride / dichloromethane / 2 h / 20 °C
4.1: 1H-imidazole; iodine; triphenylphosphine / toluene / Heating
5.1: sulfuric acid; water / 1,4-dioxane / 2 h / 80 °C
6.1: oxygen; copper(l) chloride; palladium dichloride / water; N,N-dimethyl-formamide / 4 h / 20 °C
7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / Cooling
7.2: 1 h / 0 °C
8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 90 °C
8.2: 3 h / 90 °C
With
pyridine; 1H-imidazole; dmap; bismuth(III) chloride; sulfuric acid; potassium tert-butylate; water; iodine; oxygen; sodium hydride; triphenylphosphine; copper(l) chloride; palladium dichloride;
In
1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1016/j.carres.2012.01.018
